文章：

胰腺导管腺癌中的光动力基质消融

Photodynamic Stromal Depletion in Pancreatic Ductal Adenocarcinoma

原文发布日期：16 August 2023

DOI: 10.3390/cancers15164135

类型: Article

开放获取: 是

英文摘要：

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid malignancies, with a five-year survival of less than 10%. The resistance of the disease and the associated lack of therapeutic response is attributed primarily to its dense, fibrotic stroma, which acts as a barrier to drug perfusion and permits tumour survival and invasion. As clinical trials of chemotherapy (CT), radiotherapy (RT), and targeted agents have not been successful, improving the survival rate in unresectable PDAC remains an urgent clinical need. Photodynamic stromal depletion (PSD) is a recent approach that uses visible or near-infrared light to destroy the desmoplastic tissue. Preclinical evidence suggests this can resensitise tumour cells to subsequent therapies whilst averting the tumorigenic effects of tumour–stromal cell interactions. So far, the pre-clinical studies have suggested that PDT can successfully mediate the destruction of various stromal elements without increasing the aggressiveness of the tumour. However, the complexity of this interplay, including the combined tumour promoting and suppressing effects, poses unknowns for the clinical application of photodynamic stromal depletion in PDAC.

摘要翻译： 

胰腺导管腺癌（PDAC）是最致命的实体恶性肿瘤之一，其五年生存率低于10%。该疾病的耐药性及相关治疗反应缺失主要归因于其致密纤维化的基质，这种基质不仅阻碍药物灌注，还为肿瘤存活和侵袭提供了条件。由于化疗、放疗及靶向药物的临床试验均未取得显著成效，提高不可切除PDAC患者的生存率仍是亟待解决的临床需求。光动力基质消融（PSD）是近年来兴起的一种治疗策略，利用可见光或近红外光破坏促纤维增生组织。临床前研究表明，该方法可使肿瘤细胞恢复对后续治疗的敏感性，同时避免肿瘤-基质细胞相互作用所诱发的致瘤效应。迄今为止，临床前研究证实光动力疗法能够有效介导多种基质成分的破坏，且不会增强肿瘤的侵袭性。然而，这种相互作用的复杂性——包括其兼具促进与抑制肿瘤的双重效应——使得光动力基质消融在PDAC临床应用中的效果仍存在诸多未知。

原文链接：

Photodynamic Stromal Depletion in Pancreatic Ductal Adenocarcinoma