The aim of this national population-based retrospective study was to analyze the relationship between MetS and the incidence of HNC. In this Korean population-based cohort study, 9,598,085 subjects above the age of 20 were monitored from 1 January 2009 to 31 December 2018. In the study population, a total of 10,732 individuals were newly diagnosed with HNC during the 10-year follow-up. The hazard ratio (HR), after adjusting for age, gender, smoking status, alcohol intake, and exercise, indicated that participants with MetS were at a 1.06-fold (95% CI: 1.01–1.10) higher risk of having HNC than those without MetS. Participants with MetS showed an increased risk of developing oral cavity cancer (HR, 1.12; 95% CI, 1.03–1.23) and laryngeal cancer (HR, 1.18; 95% CI, 1.09–1.27). Among the components of MetS, elevated fasting glucose (HR = 1.04, 95% CI: 1.00–1.08) and elevated blood pressure (HR = 1.08, 95% CI: 1.04–1.13) were significantly associated with an increased HR for HNC in an adjusted multivariable model. The association between HNC and MetS remained significant even among individuals who had never smoked or were ex-smokers (HR: 1.09; 95% CI: 1.04–1.15), as well as those who did not drink or were mild drinkers (HR: 1.07; 95% CI: 1.02–1.12). The findings of this cohort study suggest MetS was associated with an increased risk for some types of HNCs. The results of this study could assist with etiological investigations and prevention strategies.
这项全国性人群回顾性研究旨在分析代谢综合征（MetS）与头颈部癌症（HNC）发病率之间的关系。在这项基于韩国人群的队列研究中，我们对9,598,085名20岁以上受试者进行了从2009年1月1日至2018年12月31日的监测。在研究人群中，共有10,732人在10年随访期间新诊断为HNC。经调整年龄、性别、吸烟状况、饮酒量和运动量后，风险比（HR）显示，患有MetS的参与者罹患HNC的风险比未患MetS者高1.06倍（95% CI：1.01–1.10）。具体而言，MetS患者发生口腔癌（HR=1.12；95% CI：1.03–1.23）和喉癌（HR=1.18；95% CI：1.09–1.27）的风险显著增加。在MetS的组成成分中，空腹血糖升高（HR=1.04，95% CI：1.00–1.08）和血压升高（HR=1.08，95% CI：1.04–1.13）在调整后的多变量模型中与HNC风险增加显著相关。即使在从不吸烟或已戒烟者（HR=1.09；95% CI：1.04–1.15）以及不饮酒或轻度饮酒者（HR=1.07；95% CI：1.02–1.12）中，HNC与MetS的关联性仍然显著。本队列研究结果表明，MetS与某些类型HNC的风险增加相关。该研究结果可为病因学探索和预防策略制定提供参考。
肿瘤(癌症)患者之家