Background: The aim of this study was to evaluate the impact of pathological tumor-free margin distance on survival in SCC patients treated with surgery alone. Methods: This retrospective study included 128 patients with node-negative disease that received no adjuvant treatment. Disease-free and overall survival were analyzed according to pathological tumor-free margin distance. Results: The patients were subclassified into three resection margin category groups: “1 to 3 mm” (n = 42), “>3 to 8 mm” (n = 47) or “>8 mm” (n = 39). Thirty-nine of the 128 patients (30.5%) developed recurrent disease. Median follow-up for disease-free survival (DFS) was 6.49 years (95% CI 5.16 years; 7.62 years), and median follow-up for overall survival (OS) was 6.29 years (95% CI 5.45 years; 7.33 years). The 5-year DFS rate was 0.70 (95% CI: 0.62–0.79), and the 5-year OS rate was 0.79 (95% CI: 0.71–0.87). Regarding the survival outcome, there were no independent significant differences in either disease-free survival (DFS) (p= 0.300) or overall survival (p= 1.000) among patients within the three tumor-free resection margin categories. Multivariate analyses did not show any statistically significant association between tumor-free resection margin distance and recurrent disease or death, either when analyzed as a categorical variable or when analyzed as a continuous variable. Conclusion: The present study did not show a significant impact of pathological tumor-free resection margin distance following surgery in patients with node-negative SCC of the vulva (that did not receive adjuvant treatment) on disease-free and overall survival.
背景：本研究旨在评估病理学切缘阴性距离对仅接受手术治疗的头颈部鳞状细胞癌（SCC）患者生存的影响。方法：这项回顾性研究纳入了128例淋巴结阴性且未接受辅助治疗的患者。根据病理学切缘阴性距离分析无病生存期和总生存期。结果：患者按手术切缘距离分为三组："1至3毫米"（n=42）、">3至8毫米"（n=47）或">8毫米"（n=39）。128例患者中有39例（30.5%）出现疾病复发。无病生存期的中位随访时间为6.49年（95% CI 5.16年；7.62年），总生存期的中位随访时间为6.29年（95% CI 5.45年；7.33年）。5年无病生存率为0.70（95% CI：0.62–0.79），5年总生存率为0.79（95% CI：0.71–0.87）。在生存结果方面，三个切缘阴性距离组患者的无病生存期（p=0.300）和总生存期（p=1.000）均无独立显著差异。多变量分析显示，无论将切缘阴性距离作为分类变量还是连续变量进行分析，均未发现其与疾病复发或死亡存在统计学显著关联。结论：本研究表明，对于未接受辅助治疗的外阴淋巴结阴性鳞状细胞癌患者，术后病理学切缘阴性距离对无病生存期和总生存期无显著影响。
肿瘤(癌症)患者之家