文章：

计划CT可识别前列腺内高运动风险患者

Planning CT Identifies Patients at Risk of High Prostate Intrafraction Motion

原文发布日期：15 August 2023

DOI: 10.3390/cancers15164103

类型: Article

开放获取: 是

英文摘要：

Prostate motion (standard deviation, range of motion, and diffusion coefficient) was calculated from 4D ultrasound data of 1791 fractions of radiation therapy in N = 100 patients. The inner diameter of the lesser pelvis was obtained from transversal slices through the pubic symphysis in planning CTs. On the lateral and craniocaudal axes, motility increases significantly (t-test,p< 0.005) with the inner diameter of the lesser pelvis. A diameter of >106 mm (ca. 6th decile) is a good predictor for high prostate intrafraction motion (ca. 9th decile). The corresponding area under the receiver operator curve (AUROC) is 80% in the lateral direction, 68% to 80% in the craniocaudal direction, and 62% to 70% in the vertical direction. On the lateral x-axis, the proposed test is 100% sensitive and has a 100% negative predictive value for all three characteristics (standard deviation, range of motion, and diffusion coefficient). On the craniocaudal z-axis, the proposed test is 79% to 100% sensitive and reaches 95% to 100% negative predictive value. On the vertical axis, the proposed test still delivers 98% negative predictive value but is not particularly sensitive. Overall, the proposed predictor is able to help identify patients at risk of high prostate motion based on a single planning CT.

摘要翻译： 

本研究基于N=100名患者共计1791次放疗分次的四维超声数据，计算了前列腺运动参数（标准差、运动范围及扩散系数）。通过计划CT中耻骨联合横断面切片获取了小骨盆内径。在侧向轴和头尾轴上，前列腺运动度随小骨盆内径增大而显著增加（t检验，p<0.005）。当内径＞106毫米（约第六十分位数）时，可有效预测高前列腺分次内运动（约第九十分位数）。受试者工作特征曲线下面积（AUROC）在侧向轴为80%，头尾轴为68%-80%，垂直轴为62%-70%。在侧向x轴上，该检测方法对所有三种运动特征（标准差、运动范围和扩散系数）均具有100%的敏感度和100%的阴性预测值。在头尾z轴上，敏感度为79%-100%，阴性预测值达95%-100%。在垂直轴上，该检测仍能提供98%的阴性预测值，但敏感度相对有限。总体而言，基于单次计划CT扫描，该预测指标能够有效识别具有高前列腺运动风险的患者。

原文链接：

Planning CT Identifies Patients at Risk of High Prostate Intrafraction Motion