DTC accounts for the majority of endocrine tumors. While the incidence of thyroid cancer has been increasing globally over the past few decades, papillary thyroid carcinoma (PTC) generally shows an excellent prognosis, except in cases with aggressive clinicopathological features. This study aimed to assess the 5- and 10-year overall survival (OS) and progression-free survival (PFS) of 528 Arabic patients diagnosed with primary DTC from 1998 to 2021. Additionally, the study aimed to analyze the impact of various factors on both OS and PFS. An univariable survival analysis was conducted using Kaplan–Meier curves. The 5- and 10-year OS for patients with DTC have exceeded 95%. Additionally, PFS showed very good rates (ranging between 96.5 and 85% at 5 and 10 years, respectively). Age, male gender, risk of recurrence, and distant metastasis were identified as the main negative prognostic factors for both OS and PFS, while RAI treatment was found to be a significant factor in improving OS. Moreover, adherence to the King Hussein Cancer Center’s (KHCC) CPG demonstrated significant improvement in PFS. These findings highlight common prognostic factors and favorable outcomes in Arabic patients with DTC treated at a tertiary cancer center using standard of care approaches.
分化型甲状腺癌（DTC）占内分泌肿瘤的大多数。尽管过去几十年全球甲状腺癌发病率持续上升，但除具有侵袭性临床病理特征的病例外，乳头状甲状腺癌（PTC）通常预后良好。本研究旨在评估1998年至2021年间确诊的528例阿拉伯原发性DTC患者的5年和10年总生存期（OS）与无进展生存期（PFS），并分析多种因素对OS和PFS的影响。通过Kaplan-Meier曲线进行单变量生存分析显示，DTC患者的5年和10年OS均超过95%，PFS亦表现良好（5年和10年分别为96.5%和85%）。年龄、男性性别、复发风险及远处转移被确定为OS和PFS的主要负面预后因素，而放射性碘（RAI）治疗则是改善OS的重要积极因素。此外，遵循侯赛因国王癌症中心（KHCC）临床实践指南（CPG）显著改善了PFS。这些发现揭示了在三级癌症中心接受标准治疗的阿拉伯DTC患者中常见的预后因素及良好的临床结局。
肿瘤(癌症)患者之家