Non-alcoholic fatty liver disease (NAFLD), with its progressive form, non-alcoholic steatohepatitis (NASH), has emerged as a significant public health concern, affecting over 30% of the global population. Hepatocellular carcinoma (HCC), a complication associated with both cirrhotic and non-cirrhotic NAFLD, has shown a significant increase in incidence. A substantial proportion of NAFLD-related HCC occurs in non-cirrhotic livers, highlighting the need for improved risk stratification and surveillance strategies. This comprehensive review explores the potential role of liver ultrasound elastography as a risk assessment tool for HCC development in NAFLD and highlights the importance of effective screening tools for early, cost-effective detection and improved management of NAFLD-related HCC. The integration of non-invasive tools and algorithms into risk stratification strategies could have the capacity to enhance NAFLD-related HCC screening and surveillance effectiveness. Alongside exploring the potential advancement of non-invasive tools and algorithms for effectively stratifying HCC risk in NAFLD, we offer essential perspectives that could enable readers to improve the personalized assessment of NAFLD-related HCC risk through a more methodical screening approach.
非酒精性脂肪性肝病（NAFLD）及其进展形式——非酒精性脂肪性肝炎（NASH），已成为影响全球超过30%人口的重大公共卫生问题。肝细胞癌（HCC）作为NAFLD在肝硬化与非肝硬化阶段的共同并发症，其发病率呈现显著上升趋势。值得注意的是，相当比例的NAFLD相关HCC发生于非肝硬化肝脏，这凸显了优化风险分层与监测策略的迫切需求。本综述系统探讨了肝脏超声弹性成像作为NAFLD患者HCC发生风险评估工具的潜在价值，并强调了开发有效筛查工具对实现NAFLD相关HCC早期、经济高效检测及优化管理的重要意义。将无创检测工具与算法整合至风险分层策略中，有望提升NAFLD相关HCC筛查与监测效能。在探索无创工具与算法对NAFLD患者HCC风险进行有效分层的潜在进展的同时，本文提供了关键视角，有助于读者通过更系统化的筛查方法，提升NAFLD相关HCC风险的个体化评估水平。
肿瘤(癌症)患者之家