Vestibular schwannoma (VS) are benign cranial nerve sheath tumors of the vestibulocochlear nerve. Their incidence is mostly sporadic, but they can also be associated withNF2-related schwannomatosis (NF2), a hereditary tumor syndrome. Metastasis associated in colon cancer 1 (MACC1) is known to contribute to angiogenesis, cell growth, invasiveness, cell motility and metastasis of solid malignant cancers. In addition, MACC1 may be associated with nonsyndromic hearing impairment. Therefore, we evaluated whether MACC1 may be involved in the pathogenesis of VS. Sporadic VS, recurrent sporadic VS, NF2-associated VS, recurrent NF2-associated VS and healthy vestibular nerves were analyzed forMACC1mRNA and protein expression by quantitative polymerase chain reaction and immunohistochemistry.MACC1expression levels were correlated with the patients’ clinical course and symptoms.MACC1mRNA expression was significantly higher in sporadic VS compared to NF2-associated VS (p< 0.001). The latter expressed similar MACC1 concentrations as healthy vestibular nerves. Recurrent tumors resembled theMACC1expression of the primary tumors.MACC1mRNA expression was significantly correlated with deafness in sporadic VS patients (p= 0.034). Therefore, MACC1 might be a new molecular marker involved in VS pathogenesis.
前庭神经鞘瘤（VS）是起源于前庭蜗神经的良性颅神经鞘瘤。其发病多为散发性，但也可能与遗传性肿瘤综合征——NF2相关神经鞘瘤病（NF2）相关。已知结肠癌转移相关基因1（MACC1）可促进实体恶性肿瘤的血管生成、细胞生长、侵袭性、细胞运动及转移。此外，MACC1可能与非综合征性听力损伤相关。因此，我们评估了MACC1是否可能参与VS的发病机制。通过定量聚合酶链反应和免疫组织化学方法，我们分析了散发性VS、复发性散发性VS、NF2相关VS、复发性NF2相关VS及健康前庭神经中MACC1 mRNA及蛋白的表达情况，并将MACC1表达水平与患者的临床病程及症状进行关联分析。结果显示，散发性VS中的MACC1 mRNA表达显著高于NF2相关VS（p<0.001），而后者与健康前庭神经的MACC1表达水平相似。复发性肿瘤的MACC1表达特征与原发肿瘤相近。在散发性VS患者中，MACC1 mRNA表达与耳聋症状显著相关（p=0.034）。因此，MACC1可能成为参与VS发病机制的新分子标志物。
肿瘤(癌症)患者之家