文章：

IMP3表达作为皮肤鳞状细胞癌高风险部位的潜在肿瘤标志物：转移性cSCC中的IMP3研究

IMP3 Expression as a Potential Tumour Marker in High-Risk Localisations of Cutaneous Squamous Cell Carcinoma: IMP3 in Metastatic cSCC

原文发布日期：14 August 2023

DOI: 10.3390/cancers15164087

类型: Article

开放获取: 是

英文摘要：

Background: High IMP3 expression is correlated with a worse outcome. Until now, there have been no data about IMP3 expression and clinical outcome for high-risk localisation of squamous cell carcinoma of the skin (cSCC). Methods: One-hundred twenty-two patients with cSCC of the lip and ear were included, and IMP3 expression in the tumours was immunohistochemically assessed in different evaluation approaches. Subsequently, subgroups were analysed in a matched pair approach and correlated with clinical pathologic parameters. In the following, different IMP3 analysis methods were tested for clinical suitability. Results: We found a significant correlation between IMP3 expression and risk for lymph node metastasis, local relapse, and progression-free survival. Conclusions: On basis of our data, we suggest a prognostic benefit cutoff value for high (>50%) and low (<50%) IMP3 expression. Thus, IMP3 expression has a high scientific potential for further studies and could potentially be used as a prognostic marker in diagnostic and therapeutic decision-making.

摘要翻译： 

背景：IMP3高表达与不良预后相关。目前尚无关于皮肤鳞状细胞癌高风险部位（cSCC）中IMP3表达与临床结局关系的数据。方法：本研究纳入122例唇部和耳部cSCC患者，采用不同评估方法对肿瘤组织中IMP3表达进行免疫组化检测。随后通过配对分析方法对亚组进行解析，并与临床病理参数进行关联性研究。在此基础上，对不同IMP3分析方法进行临床适用性验证。结果：我们发现IMP3表达与淋巴结转移风险、局部复发率及无进展生存期存在显著相关性。结论：基于本研究数据，我们建议将>50%和<50%分别作为高表达与低表达的预后分界值。因此，IMP3表达具有重要的科研价值，未来可作为诊断和治疗决策中的预后标志物。

原文链接：

IMP3 Expression as a Potential Tumour Marker in High-Risk Localisations of Cutaneous Squamous Cell Carcinoma: IMP3 in Metastatic cSCC