文章：

鼻咽癌与人乳头瘤病毒感染的关联性研究

Association of Nasopharynx Cancer with Human Papillomavirus Infections

原文发布日期：13 August 2023

DOI: 10.3390/cancers15164082

类型: Article

开放获取: 是

英文摘要：

This population-based study aims to examine the association between nasopharyngeal carcinoma and human papillomavirus infections. This study included 2747 individuals aged 20 years and older who were diagnosed with nasopharynx cancer as cases and 13,735 propensity-score-matching controls. Multivariate logistic regression models were employed to quantitatively assess the association of nasopharynx cancer with human papillomavirus infections while considering age, sex, monthly income, geographic location, and urbanization level of the patient’s residence as well as diabetes, hypertension, and hyperlipidemia. Our chi-squared test indicated a significant dissimilarity in previous human papillomavirus infection rates between nasopharynx cancer patients and controls (12.7% vs. 7.2%,p< 0.001). The adjusted odds ratio (OR) for prior human papillomavirus infections was found to be significantly higher for nasopharyngeal carcinoma cases compared to controls at a value of 1.869 with confidence interval ranging from 1.640 to 2.128. Among female participants, compared to controls, the adjusted OR of prior human papillomavirus infections was 2.150 (95% CI = 1.763–2.626) in patients with nasopharynx cancer. In male participants sampled in this study, we observed a statistically significant association between prior human papillomavirus infections and nasopharynx cancer (adjusted OR = 1.689; 95% CI = 1.421–2.008). Our study indicates a noteworthy association between previous human papillomavirus infections and nasopharyngeal carcinoma.

摘要翻译： 

这项基于人群的研究旨在探讨鼻咽癌与人乳头瘤病毒感染之间的关联。本研究纳入2747名20岁及以上确诊为鼻咽癌的患者作为病例组，并采用倾向评分匹配法选取13,735名对照者。研究采用多变量逻辑回归模型，在控制年龄、性别、月收入、居住地地理位置及城市化水平，以及糖尿病、高血压和高脂血症等因素后，定量评估鼻咽癌与人乳头瘤病毒感染的关系。卡方检验结果显示，鼻咽癌患者与对照组既往人乳头瘤病毒感染率存在显著差异（12.7% vs. 7.2%，p<0.001）。经校正后，鼻咽癌病例组既往人乳头瘤病毒感染的比值比（OR）显著高于对照组，OR值为1.869（95% CI：1.640-2.128）。在女性参与者中，鼻咽癌患者既往人乳头瘤病毒感染的校正OR值为2.150（95% CI：1.763-2.626）。在男性参与者中，既往人乳头瘤病毒感染与鼻咽癌同样存在统计学显著关联（校正OR=1.689；95% CI：1.421-2.008）。本研究提示既往人乳头瘤病毒感染与鼻咽癌之间存在显著关联。

原文链接：

Association of Nasopharynx Cancer with Human Papillomavirus Infections