The cancer profile of veterinarians has received little research attention, despite the profession potentially being exposed to a wide range of known and suspected carcinogens. In this large-scale cohort study, we assessed cancer incidence in veterinarians in Denmark, Finland, Iceland, Norway, and Sweden, across more than 40 years (1961–2005). The cohort comprised 4708 veterinarians and 119,503 person-years at follow-up. The overall cancer incidence in veterinarians was close to the incidence in the total population in all countries and in all age groups. In male veterinarians, the standardized incidence ratios (SIR) in 1961–1990 were elevated for colon cancer (1.86, 95% confidence interval (CI) 1.39–2.44), prostate cancer (1.35, 95% CI 1.07–1.67), and especially skin melanoma (3.62, 95% CI 2.78–2.84), while there was no longer any statistically significant excess in the more recent follow-up period. Decreased SIRs were observed for lip cancer (0.11, 95% CI 0.00–0.62), laryngeal cancer (0.38, 95% CI 0.12–0.89), lung cancer (0.59, 95% CI 0.47–0.74), and stomach cancer (0.58, 95% CI 0.38–0.86), without a marked change in SIR over time. Non-significant excesses among male veterinarians were also observed in Hodgkin lymphoma (1961–1990 only), and leukaemia. This multi-country study indicates that there was an elevated incidence of several cancer types among male veterinarians before the 1990s but not after that. Some of the findings might rather be attributed to lifestyle factors and not directly to work conditions, but the excess risk of cancers of kidney and bladder, for example, might be related to work exposures.
兽医群体的癌症风险特征鲜有研究关注，尽管该职业可能暴露于多种已知及疑似致癌物。在这项跨越四十余年（1961-2005年）的大规模队列研究中，我们评估了丹麦、芬兰、冰岛、挪威和瑞典兽医的癌症发病率。队列共纳入4708名兽医，累计随访119,503人年。所有国家和各年龄段的兽医总体癌症发病率均接近总人群水平。在男性兽医中，1961-1990年期间结肠癌（标准化发病率比[SIR] 1.86，95%置信区间[CI] 1.39-2.44）、前列腺癌（SIR 1.35，95% CI 1.07-1.67），特别是皮肤黑色素瘤（SIR 3.62，95% CI 2.78-2.84）的标准化发病率显著升高，但在近期随访阶段未再出现统计学显著超额风险。唇癌（SIR 0.11，95% CI 0.00-0.62）、喉癌（SIR 0.38，95% CI 0.12-0.89）、肺癌（SIR 0.59，95% CI 0.47-0.74）和胃癌（SIR 0.58，95% CI 0.38-0.86）的标准化发病率显著降低，且随时间推移未见明显变化。男性兽医在霍奇金淋巴瘤（仅1961-1990年）和白血病方面也存在非显著性超额风险。这项多国研究表明，20世纪90年代前男性兽医多种癌症类型的发病率有所升高，但此后未见此现象。部分发现可能归因于生活方式因素而非直接工作条件，但肾癌和膀胱癌等超额风险可能与职业暴露相关。
肿瘤(癌症)患者之家