Several studies have suggested that single nucleotide polymorphisms (SNPs) related to vitamin D metabolism may affect CRC carcinogenesis and survival. The aim of this study was to evaluate the influence of 13 SNPs involved in the vitamin D metabolic pathway on CRC survival. We conducted an observational retrospective cohort study, which included 127 Caucasian CRC patient from the south of Spain. SNPs inVDR,CYP27B1,CYP2R1,CYP24A1, andGCgenes were analyzed by real-time polymerase chain reaction. Progression-free survival (PFS) and overall survival (OS) were assessed. Cox regression analysis adjusted for metastasis, age of diagnosis, stage (IIIB, IV or IVB), ECOG score (2–4), lymph node involvement, adjuvant chemotherapy, and no family history of CRC showed that theVDRApaI (p= 0.036),CYP24A1rs6068816 (p< 0.001), andGCrs7041 (p= 0.006) were associated with OS in patients diagnosed with CRC, andCYP24A1rs6068816 (p< 0.001) was associated with PFS adjusted for metastasis, age of diagnosis, stage (IIIB, IV or IVB), ECOG score (2–4), lymph node involvement, adjuvant chemotherapy, and no primary tumor resection. The rest of the SNPs showed no association with CRC survival. Thus, the SNPs mentioned above may have a key role as prognostic biomarkers of CRC.
多项研究表明，与维生素D代谢相关的单核苷酸多态性（SNPs）可能影响结直肠癌（CRC）的发生和生存。本研究旨在评估维生素D代谢途径中13个SNPs对CRC患者生存的影响。我们开展了一项观察性回顾性队列研究，纳入了127名来自西班牙南部的白种人CRC患者。通过实时聚合酶链反应分析了VDR、CYP27B1、CYP2R1、CYP24A1和GC基因中的SNPs。评估了无进展生存期（PFS）和总生存期（OS）。经转移、诊断年龄、分期（IIIB、IV或IVB）、ECOG评分（2-4）、淋巴结受累、辅助化疗以及无CRC家族史等因素调整后的Cox回归分析显示，VDRApaI（p=0.036）、CYP24A1rs6068816（p<0.001）和GCrs7041（p=0.006）与CRC诊断患者的OS相关；而经转移、诊断年龄、分期（IIIB、IV或IVB）、ECOG评分（2-4）、淋巴结受累、辅助化疗以及未行原发肿瘤切除等因素调整后，CYP24A1rs6068816（p<0.001）与PFS相关。其余SNPs未显示与CRC生存相关。因此，上述SNPs可能作为CRC预后生物标志物发挥关键作用。
肿瘤(癌症)患者之家