Mitochondrial dysfunction and respiratory function changes have been consistently associated with the initiation and progression of cancer. The purpose of this study was to retrospectively investigate the expression of mitochondrial tumor-suppressor and DNA-repair proteins in patients with oral squamous cell carcinoma (OSCC) and to evaluate the relationship between their expression and prognosis. We enrolled 197 patients with OSCC who underwent surgical resection between August 2013 and October 2018. Clinical, pathological, and epidemiological data were retrospectively collected from hospital records. The expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), mitochondrial transcription factor A, mitochondrial tumor suppressor gene 1, silent information regulator 3, and 8-hydroxyguanine DNA glycosylase was investigated using immunochemistry. The 3-year disease-specific survival (DSS) rates of patients showing positive expression of all selected proteins were significantly higher than those of patients showing a lack of expression. Multivariate analysis revealed that the expression of PGC-1α (hazard ratio, 4.684) and vascular invasion (hazard ratio, 5.690) can predict the DSS rate (p< 0.001). Low PGC-1α expression and vascular invasion are potential clinically effective predictors of the prognosis of OSCC.
线粒体功能障碍与呼吸功能改变始终与癌症的发生发展密切相关。本研究旨在回顾性分析口腔鳞状细胞癌（OSCC）患者中线粒体肿瘤抑制蛋白及DNA修复蛋白的表达情况，并评估其表达与预后的相关性。研究纳入2013年8月至2018年10月期间接受手术切除的197例OSCC患者，从医院病历中回顾性收集临床、病理及流行病学资料。采用免疫组化法检测过氧化物酶体增殖物激活受体γ共激活因子1α（PGC-1α）、线粒体转录因子A、线粒体肿瘤抑制基因1、沉默信息调节因子3及8-羟基鸟嘌呤DNA糖基化酶的表达水平。结果显示，所有选定蛋白均呈阳性表达患者的3年疾病特异性生存率显著高于表达缺失患者。多变量分析表明，PGC-1α表达水平（风险比4.684）与血管侵犯（风险比5.690）可作为疾病特异性生存率的独立预测指标（p<0.001）。PGC-1α低表达与血管侵犯是OSCC预后具有潜在临床效能的预测因子。
肿瘤(癌症)患者之家