Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 low-grade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2= 0.99, 95% CI 0.94–1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.
现有关于（多）酚摄入在前列腺癌风险中潜在作用的流行病学证据较为有限，且已有研究提示黄酮类化合物的摄入可能增加前列腺癌风险。本研究探讨了总（多）酚及各类别、亚类别（多）酚摄入与前列腺癌（包括临床相关亚型）风险之间的关联。欧洲癌症与营养前瞻性研究队列纳入了来自七个欧洲国家的131,425名成年男性。通过结合经过验证的地区/国家特异性饮食问卷及酚类物质数据库，评估了基线期的（多）酚摄入量。采用多变量调整的Cox比例风险模型计算风险比及其95%置信区间。在平均14年的随访期间，共确诊6,939例新发前列腺癌病例（包括3,501例低级别和710例高级别病例，2,446例局限性和1,268例晚期病例，以及914例致死性病例）。总体（多）酚摄入量与前列腺癌风险之间未观察到显著关联（HRlog2=0.99，95% CI 0.94–1.04），各前列腺癌亚型分析结果亦无显著关联。所有（多）酚类别（酚酸、黄酮类、木脂素和芪类）及其亚类摄入量与前列腺癌总体风险及各亚型风险均未发现显著关联。当前大规模前瞻性队列研究的结果不支持（多）酚摄入与前列腺癌发病率之间存在任何关联。
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