Urinary storage symptoms after low-dose-rate brachytherapy (LDR-BT) with iodine-125 have been noted to be less likely to improve to baseline compared to voiding symptoms. This study aimed to evaluate the chronological changes in the overactive bladder symptom score (OABSS) and the time-to-resolution of OABSS in patients undergoing LDR-BT. Patients with prostate cancer who underwent LDR-BT at Gifu University Hospital were enrolled. The OABSS was evaluated before and after LDR-BT. Patients were divided into the OABSS resolution and resolution delay groups, and the association between OABSS resolution delay and clinicopathological covariates was evaluated. In total, 237 patients were enrolled in this study, with a median follow-up of 88.3 months. The OABSS in both groups worsened at 3 months following operation and gradually recovered at 9 months; however, the OABSS in the resolution delay group tended to worsen again after that. In the multivariate analysis, preoperative OABSS and the change from baseline to maximal OABSS were associated with OABSS resolution. To our knowledge, this is the first study to evaluate the delayed resolution of OABSS after LDR-BT in patients with prostate cancer. A low baseline OABSS and significant changes in the OABSS from baseline were independent predictors of delayed OABSS resolution.
与排尿症状相比，碘-125低剂量率近距离放疗后的储尿症状改善至基线水平的可能性较低。本研究旨在评估接受低剂量率近距离放疗患者膀胱过度活动症症状评分的时序变化及其恢复时间。研究纳入了在岐阜大学医院接受低剂量率近距离放疗的前列腺癌患者，评估治疗前后的膀胱过度活动症症状评分。将患者分为症状缓解组和缓解延迟组，分析缓解延迟与临床病理协变量之间的关系。共237例患者纳入研究，中位随访时间88.3个月。两组患者的膀胱过度活动症症状评分均在术后3个月恶化，9个月时逐渐恢复，但缓解延迟组此后症状评分呈现再次恶化趋势。多变量分析显示，术前膀胱过度活动症症状评分及其从基线到峰值的变化与症状缓解延迟相关。据我们所知，这是首个评估前列腺癌患者低剂量率近距离放疗后膀胱过度活动症症状延迟缓解的研究。较低的基线膀胱过度活动症症状评分及其显著变化是症状延迟缓解的独立预测因素。
肿瘤(癌症)患者之家