文章：

保乳治疗乳腺癌中的肿瘤床加量放疗：术中技术与结果的综述

Tumor Bed Boost Radiotherapy in the Conservative Treatment of Breast Cancer: A Review of Intra-Operative Techniques and Outcomes

原文发布日期：8 August 2023

DOI: 10.3390/cancers15164025

类型: Review

开放获取: 是

英文摘要：

Conservative surgery is the preferred treatment in the management of breast cancer followed by adjuvant whole-breast irradiation. Since the tumor bed is the main site of relapse, boost doses are conveniently administered according to risk factors for local relapse to increase the efficacy of the treatment. The benefit of a radiation boost is well established and it can be performed by several techniques like brachytherapy, external radiation or intraoperative radiotherapy. Greater precision in localizing the tumor cavity, immediacy and increased biological response are the main advantages of intraoperative boost irradiation. This modality of treatment can be performed by means of mobile electron accelerators or low-photon X-ray devices. There is a lot of research and some published series analyzing the results of the use of an intraoperative boost as an adjuvant treatment, after neoadjuvant systemic therapy and in combination with some reconstructive surgeries. This review discusses advantages of intraoperative radiotherapy and presents the main results of a boost in terms of local control, survival, tolerance and cosmesis.

摘要翻译： 

在乳腺癌治疗中，保乳手术是首选方案，术后通常辅以全乳放射治疗。鉴于肿瘤床是主要的复发部位，可根据局部复发风险因素便捷地实施增量剂量照射，以提高治疗效果。放射增量的益处已得到广泛确认，其可通过多种技术实现，如近距离放射治疗、外照射或术中放射治疗。术中增量照射的主要优势在于能更精准定位肿瘤腔、即时实施并增强生物响应。这种治疗模式可通过移动式电子加速器或低光子能量X射线设备完成。目前已有大量研究和系列报道分析术中增量照射作为辅助治疗手段的效果，包括在新辅助系统治疗后以及与某些重建手术联合应用的情况。本综述探讨了术中放射治疗的优势，并展示了增量照射在局部控制、生存率、耐受性和美容效果方面的主要结果。

原文链接：

Tumor Bed Boost Radiotherapy in the Conservative Treatment of Breast Cancer: A Review of Intra-Operative Techniques and Outcomes