文章：

表观遗传修饰因子在乳腺癌发病机制和治疗反应中的新兴作用

Emerging Role of Epigenetic Modifiers in Breast Cancer Pathogenesis and Therapeutic Response

原文发布日期：7 August 2023

DOI: 10.3390/cancers15154005

类型: Review

开放获取: 是

英文摘要：

Breast cancer pathogenesis, treatment, and patient outcomes are shaped by tumor-intrinsic genomic alterations that divide breast tumors into molecular subtypes. These molecular subtypes often dictate viable therapeutic interventions and, ultimately, patient outcomes. However, heterogeneity in therapeutic response may be a result of underlying epigenetic features that may further stratify breast cancer patient outcomes. In this review, we examine non-genetic mechanisms that drive functional changes to chromatin in breast cancer to contribute to cell and tumor fitness and highlight how epigenetic activity may inform the therapeutic response. We conclude by providing perspectives on the future of therapeutic targeting of epigenetic enzymes, an approach that holds untapped potential to improve breast cancer patient outcomes.

摘要翻译： 

乳腺癌的发病机制、治疗方案及患者预后受肿瘤内在基因组改变的影响，这些改变将乳腺肿瘤划分为不同的分子亚型。这些分子亚型通常决定着可行的治疗干预措施，并最终影响患者预后。然而，治疗反应的异质性可能源于潜在的表观遗传特征，这些特征可能进一步对乳腺癌患者的预后进行分层。本文综述了驱动乳腺癌染色质功能改变的非遗传机制，这些机制影响细胞和肿瘤的适应性，并重点探讨表观遗传活动如何反映治疗反应。最后，我们对表观遗传酶靶向治疗的未来前景提出展望，这一治疗方法在改善乳腺癌患者预后方面具有尚未开发的潜力。

原文链接：

Emerging Role of Epigenetic Modifiers in Breast Cancer Pathogenesis and Therapeutic Response