文章：

种族和民族对接受减瘤手术联合腹腔热灌注化疗的阑尾癌患者总生存率的影响

Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy

原文发布日期：6 August 2023

DOI: 10.3390/cancers15153990

类型: Article

开放获取: 是

英文摘要：

Appendiceal cancer treatment may include cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We investigated whether patient race/ethnicity influences outcomes and overall survival for patients with appendiceal cancer who undergo CRS/HIPEC. We queried the National Cancer Database for adult patients with appendiceal cancer treated with CRS/HIPEC from 2006 to 2018. Patients were stratified by race/ethnicity: non-Hispanic White (NHW), non-Hispanic Black (NHB), Hispanic, and Other. Sociodemographics and outcomes were compared using descriptive statistics. Kaplan–Meier survival analysis and Log-rank tests assessed differences in overall survival (OS). Cox Multivariate Regression evaluated factors associated with OS. In total, 2532 patients were identified: 2098 (82.9%) NHW, 186 (7.3%) NHB, 127 (5.0%) Hispanic, and 121 (4.8%) Other patients. The sociodemographics were statistically different across groups. The perioperative and postoperative outcomes were similar. OS was significantly different by race/ethnicity (p= 0.0029). NHB patients compared to Hispanic patients had the shortest median OS (106.7 vs. 145.9 months,p= 0.0093). Race/ethnicity was independently associated with OS: NHB (HR: 2.117 [1.306, 3.431],p= 0.0023) and NHW (HR: 1.549 [1.007, 2.383],p= 0.0463) patients compared to Hispanic patients had worse survival rates. Racial/ethnic disparities exist for patients with appendiceal cancer undergoing CRS/HIPEC. Despite having similar tumor and treatment characteristics, OS is associated with patient race/ethnicity.

摘要翻译： 

阑尾癌的治疗可能包括减瘤手术联合腹腔热灌注化疗（CRS/HIPEC）。我们调查了接受CRS/HIPEC治疗的阑尾癌患者中，其种族/民族是否影响临床结局和总生存期。我们通过美国国家癌症数据库检索了2006年至2018年间接受CRS/HIPEC治疗的成年阑尾癌患者数据，并根据种族/民族分为非西班牙裔白人（NHW）、非西班牙裔黑人（NHB）、西班牙裔及其他族裔组。采用描述性统计比较社会人口学特征和临床结局。通过Kaplan-Meier生存分析和Log-rank检验评估总生存期（OS）的差异。通过Cox比例风险模型分析与OS相关的因素。共纳入2532例患者：2098例（82.9%）为NHW，186例（7.3%）为NHB，127例（5.0%）为西班牙裔，121例（4.8%）为其他族裔。各组社会人口学特征存在统计学差异。围手术期和术后结局相似。总生存期在不同种族/民族间差异显著（p=0.0029）。NHB患者相较西班牙裔患者中位总生存期最短（106.7个月 vs. 145.9个月，p=0.0093）。种族/民族与总生存期独立相关：与西班牙裔患者相比，NHB（风险比：2.117 [1.306, 3.431]，p=0.0023）和NHW（风险比：1.549 [1.007, 2.383]，p=0.0463）患者的生存率更差。接受CRS/HIPEC治疗的阑尾癌患者存在种族/民族相关的生存差异。尽管肿瘤特征和治疗方式相似，总生存期仍与患者种族/民族相关。

原文链接：

Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy