文章：

通过生物活性植物化合物靶向肺癌中的细胞信号通路

Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

原文发布日期：5 August 2023

DOI: 10.3390/cancers15153980

类型: Article

开放获取: 是

英文摘要：

Lung cancer is a heterogeneous group of malignancies with high incidence worldwide. It is the most frequently occurring cancer in men and the second most common in women. Due to its frequent diagnosis and variable response to treatment, lung cancer was reported as the top cause of cancer-related deaths worldwide in 2020. Many aberrant signaling cascades are implicated in the pathogenesis of lung cancer, including those involved in apoptosis (B cell lymphoma protein, Bcl-2-associated X protein, first apoptosis signal ligand), growth inhibition (tumor suppressor protein or gene and serine/threonine kinase 11), and growth promotion (epidermal growth factor receptor/proto-oncogenes/phosphatidylinositol-3 kinase). Accordingly, these pathways and their signaling molecules have become promising targets for chemopreventive and chemotherapeutic agents. Recent research provides compelling evidence for the use of plant-based compounds, known collectively as phytochemicals, as anticancer agents. This review discusses major contributing signaling pathways involved in the pathophysiology of lung cancer, as well as currently available treatments and prospective drug candidates. The anticancer potential of naturally occurring bioactive compounds in the context of lung cancer is also discussed, with critical analysis of their mechanistic actions presented by preclinical and clinical studies.

摘要翻译： 

肺癌是一组在全球范围内高发的异质性恶性肿瘤，男性发病率居首位，女性居第二位。由于其确诊率高且对治疗反应不一，2020年肺癌被列为全球癌症相关死亡的首要原因。许多异常信号通路参与肺癌的发病机制，涉及细胞凋亡（B细胞淋巴瘤蛋白、Bcl-2相关X蛋白、第一凋亡信号配体）、生长抑制（抑癌蛋白/基因及丝氨酸/苏氨酸激酶11）和生长促进（表皮生长因子受体/原癌基因/磷脂酰肌醇-3激酶）等过程。因此，这些通路及其信号分子已成为化学预防和化疗药物的重要靶点。最新研究为植物源性化合物（统称为植物化学物质）作为抗癌剂提供了有力证据。本文综述了肺癌病理生理学中的主要信号通路、现有治疗手段及潜在候选药物，同时探讨天然生物活性化合物在肺癌防治中的潜力，并结合临床前及临床研究对其作用机制进行批判性分析。

原文链接：

Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds