There is limited information regarding the potential association between chronic periodontitis (CP) and gastric cancer, especially in the Korean population. This study aimed to explore this relationship. This nested case–control study analyzed data from 10,174 patients with gastric cancer and 40,696 controls from the Korean National Health Insurance Service–National Sample Cohort using propensity score matching. Standardized differences were used to compare baseline characteristics between study groups. Logistic regression analyses adjusted for confounders were conducted to assess the association between history of CP and gastric cancer occurrence. CP histories and comprehensive subgroup analyses in the 1- and 2-year periods preceding the index date were evaluated. Individuals with a history of CP within the 1-year and 2-year periods showed an increased likelihood of developing gastric cancer. Subgroup analyses consistently supported these findings in male participants aged <65 years and individuals with various income levels or living in residential areas. However, no significant associations were observed among participants aged ≥65 years. In conclusion, CP may be a potential risk factor for gastric cancer development in the Korean population. Regular screening for gastric cancer may be necessary for high-risk individuals, specifically men aged <65 years with a history of CP.
目前关于慢性牙周炎（CP）与胃癌之间潜在关联的信息有限，尤其是在韩国人群中。本研究旨在探讨这一关系。这项巢式病例对照研究采用倾向评分匹配法，分析了来自韩国国民健康保险服务-国家样本队列的10,174名胃癌患者和40,696名对照者的数据。研究使用标准化差异比较了各组间的基线特征，并通过校正混杂因素的逻辑回归分析评估了慢性牙周炎病史与胃癌发生之间的关联。研究评估了索引日期前1年和2年内慢性牙周炎的病史及综合亚组分析结果。结果显示，在1年及2年内有慢性牙周炎病史的个体患胃癌的可能性增加。亚组分析一致支持这些发现在年龄<65岁的男性参与者、不同收入水平或居住地区的个体中成立。然而，在年龄≥65岁的参与者中未观察到显著关联。总之，慢性牙周炎可能是韩国人群胃癌发生的潜在危险因素。对于高危人群，特别是有慢性牙周炎病史的65岁以下男性，可能需要进行定期的胃癌筛查。
肿瘤(癌症)患者之家