The acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article, we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards.
酸性肿瘤微环境主要源于肿瘤细胞的高糖酵解速率，被视为实体肿瘤的标志性特征，并被发现在肿瘤进展中起着关键作用。近年来，随着对酸性肿瘤微环境认识的不断深入，研究表明在设计各类pH响应性纳米诊疗平台时，可利用酸性肿瘤微环境作为多层面靶标，以实现癌症的精准诊断和有效治疗。本文将重点概述如何利用这一特征性酸性肿瘤微环境作为纳米诊疗靶点，实现癌症特异性成像与治疗的最新进展，并随后探讨靶向酸性肿瘤微环境的纳米医学策略的未来发展前景。
The acidic tumor microenvironment: a target for smart cancer nano-theranostics
肿瘤(癌症)患者之家