2D nanomaterials generally exhibit enhanced physiochemical and biological functions in biomedical applications due to their high surface-to-volume ratio and surface charge. Conventional cancer chemotherapy based on nanomaterials has been hindered by their low drug loading and poor penetration in tumor tissue. To overcome these difficulties, novel materials systems are urgently needed. Hereby, the lanthanide-based porphyrin metal–organic framework (MOF) nanosheets (NSs) with promising cancer imaging/chemotherapy capacities are fabricated, which display superior performance in the drug loading and tumor tissue penetration. The biodegradable PPF-Gd NSs deliver an ultrahigh drug loading (>1500%) and demonstrate the stable and highly sensitive stimuli-responsive degradation/release for multimodal tumor imaging and cancer chemotherapy. Meanwhile, PPF-Gd NSs also exhibit excellent fluorescence and magnetic resonance imaging capability in vitro and in vivo. Compared to the traditional doxorubicin (DOX) chemotherapy, the in vivo results confirm the evident suppression of the tumor growth by the PPF-Gd/DOX drug delivery system with negligible side effects. This work further supports the potential of lanthanide-based MOF nanomaterials as biodegradable systems to promote the cancer theranostics technology development in the future.
二维纳米材料因其高表面积体积比及表面电荷特性，在生物医学应用中通常展现出增强的物理化学与生物学功能。传统基于纳米材料的癌症化疗受限于载药量低和肿瘤组织穿透性差的瓶颈。为突破这些难题，亟需开发新型材料体系。本研究成功构建了具有癌症成像/化疗双重潜力的镧基卟啉金属有机框架纳米片，该材料在载药能力和肿瘤组织穿透性方面表现卓越。可生物降解的PPF-Gd纳米片实现了超高载药量（>1500%），并展现出稳定且高灵敏度的刺激响应性降解/释放特性，适用于多模态肿瘤成像与癌症化疗。同时，PPF-Gd纳米片在体外和体内均表现出优异的荧光成像与磁共振成像能力。与传统阿霉素化疗相比，体内实验证实PPF-Gd/DOX药物递送系统能显著抑制肿瘤生长，且副作用可忽略不计。本研究成果进一步支持了镧基金属有机框架纳米材料作为可降解系统推动未来癌症诊疗一体化技术发展的潜力。
Multimodal channel cancer chemotherapy by 2D functional gadolinium metal–organic framework
肿瘤(癌症)患者之家