文章：

基质衰老会导致癌症与年龄相关的增加

Stromal senescence contributes to age-related increases in cancer

原文发布日期：2025-08-04

DOI: 10.1038/s41568-025-00840-9

类型: Review Article

开放获取: 否

英文摘要：

Ageing is a process characterized by a wide array of cellular and systemic changes that together increase the risk of developing cancer. While cell-autonomous mutations within incipient tumour cells are important, age-related changes in the microenvironment are critical partners in the transformation process and response to therapy. However, aspects of ageing that are important and the degree to which they contribute to cancer remain obscure. One of the factors that impacts ageing is increased cellular senescence but it is important to note that ageing and cellular senescence are not synonymous. We highlight open questions, including if senescent cells have phenotypically distinct impacts in aged versus young tissue, or if it is the cell type that dictates the impact of senescence on tissue homeostasis and disease. Finally, it is probable that our current definition of cellular senescence encompasses more than one mechanistically distinct cellular state; thus, we highlight phenotypic differences that have been noted across cell types and tissues of origin. This Review focuses on the role that senescent stromal cells have in cancer, with a particular emphasis on fibroblasts given the amount of work that has focused on them.

摘要翻译： 

衰老是一个以多种细胞和系统性变化为特征的过程，这些变化共同增加了患癌症的风险。虽然早期肿瘤细胞内的细胞自主突变很重要，但微环境中与年龄相关的变化在转化过程和治疗反应中也是关键因素。然而，衰老的重要方面及其对癌症的影响程度仍不明确。影响衰老的因素之一是细胞衰老的增加，但需要注意的是，衰老与细胞衰老并非同义词。我们提出了一些悬而未决的问题，包括衰老细胞在老年组织和年轻组织中是否具有表型上的不同影响，或者细胞类型是否决定了衰老对组织稳态和疾病的影响。最后，我们目前对细胞衰老的定义可能涵盖了不止一种机制不同的细胞状态；因此，我们强调了在不同细胞类型和组织来源中观察到的表型差异。本综述重点关注衰老基质细胞在癌症中的作用，特别强调了成纤维细胞，因为已有大量研究聚焦于它们。

原文链接：

Stromal senescence contributes to age-related increases in cancer