文章：

肿瘤微环境中的调节性T细胞

Regulatory T cells in the tumour microenvironment

原文发布日期：2025-06-10

DOI: 10.1038/s41568-025-00832-9

类型: Review Article

开放获取: 否

英文摘要：

The powerful suppressive capabilities of regulatory T (Treg) cells and their appreciable contribution to tumour progression make them attractive immunotherapeutic targets. However, their role in systemic immune homeostasis makes it important to find ways to specifically target tumour-infiltrating Treg cells while leaving the wider system unperturbed. It is also unknown whether therapies depleting or disrupting the function of tumour-infiltrating Treg cells will provide the greatest efficacy while limiting immune-related adverse events. In addition, Treg cells share much of their biology with conventional CD4+ T cells, introducing challenges when designing targeted immunotherapies. In this Review, we discuss recent advances in differentiating tumour-infiltrating Treg cells from their systemic and tissue-resident counterparts and understanding how the biology of tumour-infiltrating Treg cells differs from conventional CD4+ T cells. We also discuss how recent technological advances may enable the study of tumour-infiltrating Treg cells in even greater detail, helping to identify new targets for next-generation immunotherapeutic drugs.

摘要翻译： 

调节性T细胞强大的抑制能力及其对肿瘤进展的重要贡献，使其成为极具吸引力的免疫治疗靶点。然而，这类细胞在全身免疫稳态中的作用意味着，必须找到特异性靶向肿瘤浸润性Treg细胞而不影响整体免疫系统的方法。目前尚不清楚，清除或破坏肿瘤浸润性Treg细胞功能的疗法是否能实现最佳疗效并限制免疫相关不良事件。此外，Treg细胞与常规CD4+ T细胞在生物学特性上高度相似，这为靶向免疫疗法的设计带来了挑战。本文综述了在区分肿瘤浸润性Treg细胞与全身性及组织驻留性Treg细胞方面的最新进展，并探讨了肿瘤浸润性Treg细胞与常规CD4+ T细胞在生物学特性上的差异。同时，我们还分析了最新技术进展如何能更精细地研究肿瘤浸润性Treg细胞，从而为新一代免疫治疗药物识别新的靶点。

原文链接：

Regulatory T cells in the tumour microenvironment