文章：

破坏γδT细胞激活和抑制受体之间的平衡，以实现有效的癌症免疫治疗

Disrupting the balance between activating and inhibitory receptors of γδT cells for effective cancer immunotherapy

原文发布日期：2025-06-02

DOI: 10.1038/s41568-025-00830-x

类型: Review Article

开放获取: 否

英文摘要：

γδT cell biology in cancer has been studied for decades but remains poorly understood mainly due to species differences in preclinical models and a lack of appropriate analytical tools. This lack of knowledge has hindered the clinical translation of promising therapeutic concepts. In recent years, advanced single-cell analysis techniques and comprehensive protein–protein interaction studies have transformed our understanding of γδT cells and their receptors. This insight has revealed new opportunities and challenges in harnessing γδT cells for therapeutic purposes. In this context, we will discuss the latest findings in γδT cell biology, with a special focus on their role in cancer immune therapies. We will explore strategies to overcome tolerance and shift the balance of γδT cells and their receptors towards antitumour efficacy, which has the potential to successfully translate into various engineering approaches in cancer immunotherapy.

摘要翻译： 

γδT细胞在癌症生物学中的研究已历经数十年，但由于临床前模型的物种差异及缺乏合适的分析工具，其机制仍未被充分理解。这种认知缺失阻碍了具有潜力的治疗理念向临床转化。近年来，先进的单细胞分析技术和全面的蛋白质相互作用研究重塑了我们对γδT细胞及其受体的理解。这一突破为利用γδT细胞进行治疗带来了新的机遇与挑战。本文将重点探讨γδT细胞生物学的最新发现，特别关注其在癌症免疫治疗中的作用。我们将研究克服耐受性、调整γδT细胞及其受体平衡以增强抗肿瘤效应的策略，这些策略有望成功转化为癌症免疫治疗中的多种工程化方法。

原文链接：

Disrupting the balance between activating and inhibitory receptors of γδT cells for effective cancer immunotherapy