文章：

糖代谢酶和代谢物在癌症中的兼职功能

Moonlighting functions of glucose metabolic enzymes and metabolites in cancer

原文发布日期：2025-04-02

DOI: 10.1038/s41568-025-00800-3

类型: Review Article

开放获取: 否

英文摘要：

Glucose metabolic enzymes and their metabolites not only provide energy and building blocks for synthesizing macromolecules but also possess non-canonical or moonlighting functions in response to extracellular and intracellular signalling. These moonlighting functions modulate various cellular activities, including gene expression, cell cycle progression, DNA repair, autophagy, senescence and apoptosis, cell proliferation, remodelling of the tumour microenvironment and immune responses. These functions integrate glucose metabolism with other essential cellular activities, driving cancer progression. Targeting these moonlighting functions could open new therapeutic avenues and lead to cancer-specific treatments.

摘要翻译： 

葡萄糖代谢酶及其代谢产物不仅为合成大分子提供能量和构建模块，还能响应细胞内外信号传导发挥非经典或多功能作用。这些多功能作用调控多种细胞活动，包括基因表达、细胞周期进程、DNA修复、自噬、衰老与凋亡、细胞增殖、肿瘤微环境重塑及免疫应答。这些功能将葡萄糖代谢与其他关键细胞活动相整合，从而驱动癌症进展。靶向这些多功能作用有望开辟新的治疗途径，催生癌症特异性疗法。

原文链接：

Moonlighting functions of glucose metabolic enzymes and metabolites in cancer