文章：

癌症中的纤维炎性反应

The fibroinflammatory response in cancer

原文发布日期：2025-03-17

DOI: 10.1038/s41568-025-00798-8

类型: Review Article

开放获取: 否

英文摘要：

Fibroinflammation refers to the highly integrated fibrogenic and inflammatory responses mediated by the concerted function of fibroblasts and innate immune cells in response to tissue perturbation. This process underlies the desmoplastic remodelling of the tumour microenvironment and thus plays an important role in tumour initiation, growth and metastasis. More specifically, fibroinflammation alters the biochemical and biomechanical signalling in malignant cells to promote their proliferation and survival and further supports an immunosuppressive microenvironment by polarizing the immune status of tumours. Additionally, the presence of fibroinflammation is often associated with therapeutic resistance. As such, there is increasing interest in targeting this process to normalize the tumour microenvironment and thus enhance the treatment of solid tumours. Herein, we review advances made in unravelling the complexity of cancer-associated fibroinflammation that can inform the rational design of therapies targeting this.

摘要翻译： 

纤维炎症是指由成纤维细胞和先天免疫细胞协同作用介导的高度整合的纤维生成和炎症反应，以应对组织扰动。该过程构成了肿瘤微环境促纤维增生性重塑的基础，因此在肿瘤的发生、生长和转移中发挥重要作用。具体而言，纤维炎症通过改变恶性细胞的生化和生物力学信号促进其增殖和存活，并通过极化肿瘤的免疫状态进一步支持免疫抑制微环境。此外，纤维炎症的存在通常与治疗抵抗相关。因此，靶向这一过程以正常化肿瘤微环境、从而增强实体瘤治疗的效果正受到日益关注。本文综述了揭示癌症相关纤维炎症复杂性的最新进展，这些进展可为合理设计靶向该过程的疗法提供依据。

原文链接：

The fibroinflammatory response in cancer