文章：

肿瘤中的树突状细胞成熟

Dendritic cell maturation in cancer

原文发布日期：2025-02-07

DOI: 10.1038/s41568-024-00787-3

类型: Review Article

开放获取: 否

英文摘要：

Dendritic cells (DCs) are specialized antigen-presenting cells that are present at low abundance in the circulation and tissues; they serve as crucial immune sentinels by continually sampling their environment, migrating to secondary lymphoid organs and shaping adaptive immune responses through antigen presentation. Owing to their ability to orchestrate tolerogenic or immunogenic responses to a specific antigen, DCs have a pivotal role in antitumour immunity and the response to immune checkpoint blockade and other immunotherapeutic approaches. The multifaceted functions of DCs are acquired through a complex, multistage process called maturation. Although the role of inflammatory triggers in driving DC maturation was established decades ago, less is known about DC maturation in non-inflammatory contexts, such as during homeostasis and in cancer. The advent of single-cell technologies has enabled an unbiased, high-dimensional characterization of various DC states, including mature DCs. This approach has clarified the molecular programmes associated with DC maturation and also revealed how cancers exploit these pathways to subvert immune surveillance. In this Review, we discuss the mechanisms by which cancer disrupts DC maturation and highlight emerging therapeutic opportunities to modulate DC states. These insights could inform the development of DC-centric immunotherapies, expanding the arsenal of strategies to enhance antitumour immunity.

摘要翻译： 

树突状细胞（DCs）是一类特殊的抗原呈递细胞，在循环系统和组织中含量较低；它们通过持续采样周围环境、迁移至次级淋巴器官并通过抗原呈递塑造适应性免疫应答，从而发挥关键免疫哨兵作用。由于能够协调对特定抗原的免疫耐受性或免疫原性反应，树突状细胞在抗肿瘤免疫及应对免疫检查点阻断和其他免疫疗法中具有核心地位。树突状细胞的多方面功能是通过一个称为"成熟"的复杂多阶段过程获得的。尽管数十年前就已明确炎症触发因子在驱动树突状细胞成熟中的作用，但对于非炎症背景下（如稳态期间和癌症状态下）树突状细胞的成熟过程仍知之甚少。单细胞技术的出现使得能够对包括成熟树突状细胞在内的各种状态进行无偏倚、高维度的表征。这种方法不仅阐明了与树突状细胞成熟相关的分子程序，还揭示了癌症如何利用这些途径破坏免疫监视。本文综述了癌症破坏树突状细胞成熟的机制，并重点探讨了调控树突状细胞状态的新兴治疗策略。这些见解有望为开发以树突状细胞为核心的免疫疗法提供指导，从而扩充增强抗肿瘤免疫的策略库。

原文链接：

Dendritic cell maturation in cancer