文章：

肿瘤和宿主之间的代谢相互作用塑造了肿瘤的宏观环境

Metabolic interplays between the tumour and the host shape the tumour macroenvironment

原文发布日期：2025-01-20

DOI: 10.1038/s41568-024-00786-4

类型: Review Article

开放获取: 否

英文摘要：

Metabolic reprogramming of cancer cells and the tumour microenvironment are pivotal characteristics of cancers, and studying these processes offer insights and avenues for cancer diagnostics and therapeutics. Recent advancements have underscored the impact of host systemic features, termed macroenvironment, on facilitating cancer progression. During tumorigenesis, these inherent features of the host, such as germline genetics, immune profile and the metabolic status, influence how the body responds to cancer. In parallel, as cancer grows, it induces systemic effects beyond the primary tumour site and affects the macroenvironment, for example, through inflammation, the metabolic end-stage syndrome of cachexia, and metabolic dysregulation. Therefore, understanding the intricate metabolic interplay between the tumour and the host is a growing frontier in advancing cancer diagnosis and therapy. In this Review, we explore the specific contribution of the metabolic fitness of the host to cancer initiation, progression and response to therapy. We then delineate the complex metabolic crosstalk between the tumour, the microenvironment and the host, which promotes disease progression to metastasis and cachexia. The metabolic relationships among the host, cancer pathogenesis and the consequent responsive systemic manifestations during cancer progression provide new perspectives for mechanistic cancer therapy and improved management of patients with cancer.

摘要翻译： 

癌细胞和肿瘤微环境的代谢重编程是癌症的关键特征，研究这些过程为癌症诊断和治疗提供了见解与途径。最新研究强调了宿主系统性特征（称为宏观环境）对促进癌症进展的影响。在肿瘤发生过程中，宿主的这些固有特征（如种系遗传学、免疫谱和代谢状态）会影响机体对癌症的反应。与此同时，随着癌症的发展，它会引发原发肿瘤部位以外的系统性效应，并通过炎症、恶病质代谢终末期综合征及代谢失调等途径影响宏观环境。因此，理解肿瘤与宿主之间复杂的代谢相互作用正成为推进癌症诊断和治疗的前沿领域。本综述中，我们探讨了宿主代谢适应性对癌症发生、发展及治疗反应的具体作用，进而阐述了肿瘤、微环境与宿主之间促进疾病进展至转移和恶病质的复杂代谢互作。宿主、癌症发病机制以及癌症进展过程中相应系统性表现之间的代谢关系，为癌症机制治疗和改善患者管理提供了新视角。

原文链接：

Metabolic interplays between the tumour and the host shape the tumour macroenvironment