文章：

癌症诱导的远端器官的系统性预处理：为转移细胞建立一个生态位

Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells

原文发布日期：2024-10-10

DOI: 10.1038/s41568-024-00752-0

类型: Review Article

开放获取: 否

英文摘要：

From their early genesis, tumour cells integrate with the surrounding normal cells to form an abnormal structure that is tightly integrated with the host organism via blood and lymphatic vessels and even neural associations. Using these connections, emerging cancers send a plethora of mediators that efficiently perturb the entire organism and induce changes in distant tissues. These perturbations serendipitously favour early metastatic establishment by promoting a more favourable tissue environment (niche) that supports the persistence of disseminated tumour cells within a foreign tissue. Because the establishment of early metastatic niches represents a key limiting step for metastasis, the creation of a more suitable pre-conditioned tissue strongly enhances metastatic success. In this Review, we provide an updated view of the mechanisms and mediators of primary tumours described so far that induce a pro-metastatic conditioning of distant organs, which favours early metastatic niche formation. We reflect on the nature of cancer-induced systemic conditioning, considering that non-cancer-dependent perturbations of tissue homeostasis are also able to trigger pro-metastatic conditioning. We argue that a more holistic view of the processes catalysing metastatic progression is needed to identify preventive or therapeutic opportunities.

摘要翻译： 

从早期发生开始，肿瘤细胞就与周围正常细胞整合，形成通过血管、淋巴管甚至神经关联与宿主机体紧密相连的异常结构。利用这些连接，新兴癌症释放大量介质，有效扰乱整个机体并诱导远端组织改变。这些扰动通过营造更有利的组织环境（微环境）偶然促进早期转移灶的形成，从而支持播散肿瘤细胞在异质组织中的存活。由于早期转移微环境的建立是转移过程中的关键限制步骤，创建更适宜的预适应组织可显著提升转移成功率。本综述针对原发性肿瘤诱导远端器官促转移预适应的机制与介质提供最新见解，重点关注其如何促进早期转移微环境形成。我们反思癌症诱导系统性预适应的本质，并考虑非癌症依赖的组织稳态扰动同样可能触发促转移预适应。我们认为需要以更整体的视角审视催化转移进展的过程，以识别预防或治疗机遇。

原文链接：

Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells