文章：

巨噬细胞和T细胞在代谢紊乱相关癌症中的作用

Macrophages and T cells in metabolic disorder-associated cancers

原文发布日期：2024-10-01

DOI: 10.1038/s41568-024-00743-1

类型: Review Article

开放获取: 否

英文摘要：

Cancer and metabolic disorders have emerged as major global health challenges, reaching epidemic levels in recent decades. Often viewed as separate issues, metabolic disorders are shown by mounting evidence to heighten cancer risk and incidence. The intricacies underlying this connection are still being unraveled and encompass a complex interplay between metabolites, cancer cells and immune cells within the tumour microenvironment (TME). Here, we outline the interplay between metabolic and immune cell dysfunction in the context of three highly prevalent metabolic disorders, namely obesity; two associated liver diseases, metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH); and type 2 diabetes. We focus primarily on macrophages and T cells, the critical roles of which in dictating inflammatory response and immune surveillance in metabolic disorder-associated cancers are widely reported. Moreover, considering the ever-increasing number of patients prescribed with metabolism disorder-altering drugs and diets in recent years, we discuss how these therapies modulate systemic and local immune phenotypes, consequently impacting cancer malignancy. Collectively, unraveling the determinants of metabolic disorder-associated immune landscape and their role in fuelling cancer malignancy will provide a framework essential to therapeutically address these highly prevalent diseases.

摘要翻译： 

癌症与代谢性疾病已成为全球重大健康挑战，近几十年来呈现流行态势。尽管常被视为独立问题，但越来越多证据表明代谢性疾病会加剧癌症的风险和发病率。这一关联背后的复杂机制仍在探索中，涉及肿瘤微环境（TME）中代谢物、癌细胞和免疫细胞之间错综复杂的相互作用。本文围绕三种高发代谢性疾病——肥胖症；两种相关肝病，即代谢功能障碍相关脂肪性肝病（MASLD）和代谢功能障碍相关脂肪性肝炎（MASH）；以及2型糖尿病，阐述代谢与免疫细胞功能障碍之间的相互作用。我们重点聚焦巨噬细胞和T细胞，这两类细胞在代谢性疾病相关癌症中调控炎症反应和免疫监视的关键作用已得到广泛报道。此外，考虑到近年来接受代谢调节药物及饮食干预的患者数量持续增长，我们探讨了这些疗法如何调控全身及局部免疫表型，进而影响癌症恶性进展。总之，揭示代谢性疾病相关免疫格局的决定因素及其在促进癌症恶性化中的作用，将为治疗这些高发疾病提供不可或缺的理论框架。

原文链接：

Macrophages and T cells in metabolic disorder-associated cancers