文章：

在实体肿瘤中，CAF诱导的控制T细胞状态和定位的物理约束

CAF-induced physical constraints controlling T cell state and localization in solid tumours

原文发布日期：2024-09-09

DOI: 10.1038/s41568-024-00740-4

类型: Review Article

开放获取: 否

英文摘要：

Solid tumours comprise cancer cells that engage in continuous interactions with non-malignant cells and with acellular components, forming the tumour microenvironment (TME). The TME has crucial and diverse roles in tumour progression and metastasis, and substantial efforts have been dedicated into understanding the functions of different cell types within the TME. These efforts highlighted the importance of non-cell-autonomous signalling in cancer, mediating interactions between the cancer cells, the immune microenvironment and the non-immune stroma. Much of this non-cell-autonomous signalling is mediated through acellular components of the TME, known as the extracellular matrix (ECM), and controlled by the cells that secrete and remodel the ECM — the cancer-associated fibroblasts (CAFs). In this Review, we delve into the complex crosstalk among cancer cells, CAFs and immune cells, highlighting the effects of CAF-induced ECM remodelling on T cell functions and offering insights into the potential of targeting ECM components to improve cancer therapies.

摘要翻译： 

实体肿瘤由癌细胞组成，这些细胞与非恶性细胞及无细胞成分持续相互作用，形成肿瘤微环境（TME）。TME在肿瘤进展和转移中具有关键且多样化的作用，大量研究致力于解析TME中不同细胞类型的功能。这些研究揭示了癌症中非细胞自主信号传递的重要性——它介导着癌细胞、免疫微环境与非免疫基质之间的相互作用。此类信号大多通过TME的无细胞成分（即细胞外基质ECM）进行传递，并由分泌和重塑ECM的细胞——癌症相关成纤维细胞（CAFs）所调控。本文深入探讨癌细胞、CAFs与免疫细胞之间复杂的相互作用，重点关注CAF诱导的ECM重塑对T细胞功能的影响，并为靶向ECM成分以改善癌症治疗提供见解。

原文链接：

CAF-induced physical constraints controlling T cell state and localization in solid tumours