文章：

靶向肿瘤血管：从血管破坏到血管促进

Targeting the tumour vasculature: from vessel destruction to promotion

原文发布日期：2024-08-29

DOI: 10.1038/s41568-024-00736-0

类型: Review Article

开放获取: 否

英文摘要：

As angiogenesis was recognized as a core hallmark of cancer growth and survival, several strategies have been implemented to target the tumour vasculature. Yet to date, attempts have rarely been so diverse, ranging from vessel growth inhibition and destruction to vessel normalization, reprogramming and vessel growth promotion. Some of these strategies, combined with standard of care, have translated into improved cancer therapies, but their successes are constrained to certain cancer types. This Review provides an overview of these vascular targeting approaches and puts them into context based on our subsequent improved understanding of the tumour vasculature as an integral part of the tumour microenvironment with which it is functionally interlinked. This new knowledge has already led to dual targeting of the vascular and immune cell compartments and sets the scene for future investigations of possible alternative approaches that consider the vascular link with other tumour microenvironment components for improved cancer therapy.

摘要翻译： 

随着血管生成被确认为癌症生长和生存的核心标志，多种靶向肿瘤血管系统的策略已得以实施。然而迄今为止，这些尝试很少如此多样化，范围从抑制和破坏血管生长，到血管正常化、重编程及促进血管生长。其中一些策略与标准治疗相结合，已转化为改进的癌症疗法，但其成功仅限于某些癌症类型。本综述概述了这些血管靶向方法，并基于我们随后对肿瘤血管系统作为肿瘤微环境不可分割部分且功能相互关联的新认识，将这些方法置于相应背景中。这一新认识已导致对血管和免疫细胞区室的双重靶向，并为未来研究可能考虑血管与其他肿瘤微环境组分联系的替代方法以改进癌症治疗奠定了基础。

原文链接：

Targeting the tumour vasculature: from vessel destruction to promotion