文章：

环状RNA在癌症中的作用

Circular RNA in cancer

原文发布日期：2024-07-29

DOI: 10.1038/s41568-024-00721-7

类型: Review Article

开放获取: 否

英文摘要：

Over the past decade, circular RNA (circRNA) research has evolved into a bona fide research field shedding light on the functional consequence of this unique family of RNA molecules in cancer. Although the method of formation and the abundance of circRNAs can differ from their cognate linear mRNA, the spectrum of interacting partners and their resultant cellular functions in oncogenesis are analogous. However, with 10 times more diversity in circRNA variants compared with linear RNA variants, combined with their hyperstability in the cell, circRNAs are equipped to influence every stage of oncogenesis. This is an opportune time to address the breadth of circRNA in cancer focused on their spatiotemporal expression, mutations in biogenesis factors and contemporary functions through each stage of cancer. In this Review, we highlight examples of functional circRNAs in specific cancers, which satisfy critical criteria, including their physical co-association with the target and circRNA abundance at stoichiometrically valid quantities. These considerations are essential to develop strategies for the therapeutic exploitation of circRNAs as biomarkers and targeted anticancer agents.

摘要翻译： 

在过去十年中，环状RNA研究已发展成为一个真正的研究领域，揭示了这一独特RNA分子家族在癌症中的功能影响。虽然环状RNA的形成方式及其丰度可能不同于其同源线性mRNA，但其相互作用伙伴谱系及其在肿瘤发生中的细胞功能具有相似性。然而，与线性RNA变体相比，环状RNA变体具有十倍以上的多样性，加之其在细胞中的超稳定性，使得环状RNA能够影响肿瘤发生的每个阶段。当前正是探讨环状RNA在癌症中广泛作用的恰当时机，重点关注其时空表达特征、生物发生因子突变以及贯穿癌症各阶段的当代功能。本综述通过具体癌症案例重点展示了满足关键标准的功能性环状RNA，包括其与靶标的物理共关联性以及符合化学计量有效量的环状RNA丰度。这些考量对于制定环状RNA作为生物标志物和靶向抗癌药物的治疗开发策略至关重要。

原文链接：

Circular RNA in cancer