文章：

针对乳腺癌免疫微环境的研究

Towards targeting the breast cancer immune microenvironment

原文发布日期：2024-07-05

DOI: 10.1038/s41568-024-00714-6

类型: Review Article

开放获取: 否

英文摘要：

The tumour immune microenvironment is shaped by the crosstalk between cancer cells, immune cells, fibroblasts, endothelial cells and other stromal components. Although the immune tumour microenvironment (TME) serves as a source of therapeutic targets, it is also considered a friend or foe to tumour-directed therapies. This is readily illustrated by the importance of T cells in triple-negative breast cancer (TNBC), culminating in the advent of immune checkpoint therapy in combination with cytotoxic chemotherapy as standard of care for both early and advanced-stage TNBC, as well as recent promising signs of efficacy in a subset of hormone receptor-positive disease. In this Review, we discuss the various components of the immune TME in breast cancer and therapies that target or impact the immune TME, as well as the complexity of host physiology.

摘要翻译： 

肿瘤免疫微环境由癌细胞、免疫细胞、成纤维细胞、内皮细胞及其他基质成分之间的相互作用共同塑造。尽管免疫肿瘤微环境（TME）是治疗靶点的来源，但它亦被视为肿瘤靶向治疗的"友军或敌军"。这一点在三阴性乳腺癌（TNBC）中T细胞的重要性上得到充分体现：T细胞的关键作用最终催生了免疫检查点疗法联合细胞毒性化疗，使其成为早期及晚期TNBC的标准治疗方案，同时在部分激素受体阳性乳腺癌中也展现出近期令人鼓舞的疗效迹象。本综述将探讨乳腺癌免疫微环境的各组成要素、靶向或影响免疫微环境的治疗策略，以及宿主生理机制的复杂性。

原文链接：

Towards targeting the breast cancer immune microenvironment