文章：

癌症类器官2.0：模拟肿瘤免疫微环境的复杂性

Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment

原文发布日期：2024-07-08

DOI: 10.1038/s41568-024-00706-6

类型: Review Article

开放获取: 否

英文摘要：

The development of neoplasia involves a complex and continuous interplay between malignantly transformed cells and the tumour microenvironment (TME). Cancer immunotherapies targeting the immune TME have been increasingly validated in clinical trials but response rates vary substantially between tumour histologies and are often transient, idiosyncratic and confounded by resistance. Faithful experimental models of the patient-specific tumour immune microenvironment, capable of recapitulating tumour biology and immunotherapy effects, would greatly improve patient selection, target identification and definition of resistance mechanisms for immuno-oncology therapeutics. In this Review, we discuss currently available and rapidly evolving 3D tumour organoid models that capture important immune features of the TME. We highlight diverse opportunities for organoid-based investigations of tumour immunity, drug development and precision medicine.

摘要翻译： 

肿瘤发生发展涉及恶性转化细胞与肿瘤微环境之间复杂且持续的相互作用。针对免疫性肿瘤微环境的癌症免疫疗法已在临床试验中得到越来越多验证，但不同肿瘤组织学类型的应答率差异显著，且往往具有短暂性、特异质性并与耐药现象相互交织。能够重现肿瘤生物学特性及免疫疗法效应的患者特异性肿瘤免疫微环境忠实实验模型，将极大改善免疫肿瘤治疗的患者筛选、靶点识别及耐药机制界定。本篇综述中，我们探讨当前可用且快速发展的三维肿瘤类器官模型，这些模型能捕捉肿瘤微环境的关键免疫特征。我们重点阐述基于类器官的肿瘤免疫研究、药物开发和精准医学所提供的多种机遇。

原文链接：

Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment