文章：

三维纤维结构在癌症中的重要性及其对生物材料模型设计的影响

The importance of 3D fibre architecture in cancer and implications for biomaterial model design

原文发布日期：2024-06-17

DOI: 10.1038/s41568-024-00704-8

类型: Review Article

开放获取: 否

英文摘要：

The need for improved prediction of clinical response is driving the development of cancer models with enhanced physiological relevance. A new concept of ‘precision biomaterials’ is emerging, encompassing patient-mimetic biomaterial models that seek to accurately detect, treat and model cancer by faithfully recapitulating key microenvironmental characteristics. Despite recent advances allowing tissue-mimetic stiffness and molecular composition to be replicated in vitro, approaches for reproducing the 3D fibre architectures found in tumour extracellular matrix (ECM) remain relatively unexplored. Although the precise influences of patient-specific fibre architecture are unclear, we summarize the known roles of tumour fibre architecture, underlining their implications in cell–matrix interactions and ultimately clinical outcome. We then explore the challenges in reproducing tissue-specific 3D fibre architecture(s) in vitro, highlighting relevant biomaterial fabrication techniques and their benefits and limitations. Finally, we discuss imaging and image analysis techniques (focussing on collagen I-optimized approaches) that could hold the key to mapping tumour-specific ECM into high-fidelity biomaterial models. We anticipate that an interdisciplinary approach, combining materials science, cancer research and image analysis, will elucidate the role of 3D fibre architecture in tumour development, leading to the next generation of patient-mimetic models for mechanistic studies and drug discovery.

摘要翻译： 

对改进临床反应预测的需求正推动着具有增强生理相关性的癌症模型的发展。"精准生物材料"这一新概念正在兴起，它涵盖了患者模拟生物材料模型，这些模型通过忠实再现关键微环境特征来寻求准确检测、治疗和模拟癌症。尽管最近的技术进步允许在体外复制组织模拟的硬度和分子组成，但重现肿瘤细胞外基质（ECM）中三维纤维结构的方法仍相对未被探索。尽管患者特异性纤维结构的确切影响尚不清楚，但我们总结了肿瘤纤维结构的已知作用，强调了它们在细胞-基质相互作用以及最终临床结果中的意义。然后，我们探讨了在体外复制组织特异性三维纤维结构所面临的挑战，重点介绍了相关的生物材料制造技术及其优点和局限性。最后，我们讨论了成像和图像分析技术（侧重于胶原蛋白I优化的方法），这些技术可能掌握将肿瘤特异性ECM映射到高保真生物材料模型的关键。我们预计，一种结合材料科学、癌症研究和图像分析的跨学科方法将阐明三维纤维结构在肿瘤发展中的作用，从而催生用于机理研究和药物发现的下一代患者模拟模型。

原文链接：

The importance of 3D fibre architecture in cancer and implications for biomaterial model design