文章：

淋巴管在癌症免疫治疗的时代

Lymphatic vessels in the age of cancer immunotherapy

原文发布日期：2024-04-11

DOI: 10.1038/s41568-024-00681-y

类型: Review Article

开放获取: 否

英文摘要：

Lymphatic transport maintains homeostatic health and is necessary for immune surveillance, and yet lymphatic growth is often associated with solid tumour development and dissemination. Although tumour-associated lymphatic remodelling and growth were initially presumed to simply expand a passive route for regional metastasis, emerging research puts lymphatic vessels and their active transport at the interface of metastasis, tumour-associated inflammation and systemic immune surveillance. Here, we discuss active mechanisms through which lymphatic vessels shape their transport function to influence peripheral tissue immunity and the current understanding of how tumour-associated lymphatic vessels may both augment and disrupt antitumour immune surveillance. We end by looking forward to emerging areas of interest in the field of cancer immunotherapy in which lymphatic vessels and their transport function are likely key players: the formation of tertiary lymphoid structures, immune surveillance in the central nervous system, the microbiome, obesity and ageing. The lessons learnt support a working framework that defines the lymphatic system as a key determinant of both local and systemic inflammatory networks and thereby a crucial player in the response to cancer immunotherapy.

摘要翻译： 

淋巴运输维持体内稳态健康，并对免疫监视至关重要，然而淋巴生长常与实体瘤的发展和扩散相关联。尽管肿瘤相关的淋巴重塑和生长最初被认为仅是区域转移的被动途径扩展，但新兴研究将淋巴管及其主动运输置于转移、肿瘤相关炎症和系统性免疫监视的交界点。本文探讨了淋巴管通过主动机制塑造其运输功能以影响外周组织免疫的方式，以及当前对肿瘤相关淋巴管如何既增强又破坏抗肿瘤免疫监视的理解。最后，我们展望了癌症免疫治疗领域新兴的关注方向——淋巴管及其运输功能可能在其中发挥关键作用：三级淋巴结构的形成、中枢神经系统的免疫监视、微生物组、肥胖与衰老。这些研究结果支持了一个工作框架，该框架将淋巴系统定义为局部和全身炎症网络的关键决定因素，从而成为响应癌症免疫治疗的重要参与者。

原文链接：

Lymphatic vessels in the age of cancer immunotherapy