文章：

靶向转座因子用于癌症治疗

Towards targeting transposable elements for cancer therapy

原文发布日期：2024-01-16

DOI: 10.1038/s41568-023-00653-8

类型: Review Article

开放获取: 否

英文摘要：

Transposable elements (TEs) represent almost half of the human genome. Historically deemed ‘junk DNA’, recent technological advancements have stimulated a wave of research into the functional impact of TEs on gene-regulatory networks in evolution and development, as well as in diseases including cancer. The genetic and epigenetic evolution of cancer involves the exploitation of TEs, whereby TEs contribute directly to cancer-specific gene activities. This Review provides a perspective on the role of TEs in cancer as being a ‘double-edged sword’, both promoting cancer evolution and representing a vulnerability that could be exploited in cancer therapy. We discuss how TEs affect transcriptome regulation and other cellular processes in cancer. We highlight the potential of TEs as therapeutic targets for cancer. We also summarize technical hurdles in the characterization of TEs with genomic assays. Last, we outline open questions and exciting future research avenues.

摘要翻译： 

可转座元件约占人类基因组的一半。历史上曾被称为"垃圾DNA"，但近年来的技术进步推动了对转座元件功能影响的研究浪潮，涉及基因调控网络在进化、发育以及癌症等疾病中的作用。癌症的表观遗传进化涉及对可转座元件的利用，这些元件直接参与癌症特异性基因活动。本综述从"双刃剑"视角探讨可转座元件在癌症中的作用——既促进癌症进化，又代表可被癌症疗法利用的脆弱点。我们讨论可转座元件如何影响癌症中的转录组调控及其他细胞过程，重点探讨其作为癌症治疗靶点的潜力，同时总结了基因组分析中表征可转座元件面临的技术障碍，最后提出待解决的科学问题和未来值得探索的研究方向。

原文链接：

Towards targeting transposable elements for cancer therapy