文章：

趋化因子如何组织肿瘤微环境

How chemokines organize the tumour microenvironment

原文发布日期：2023-12-08

DOI: 10.1038/s41568-023-00635-w

类型: Review Article

开放获取: 否

英文摘要：

For our immune system to contain or eliminate malignant solid tumours, both myeloid and lymphoid haematopoietic cells must not only extravasate from the bloodstream into the tumour tissue but also further migrate to various specialized niches of the tumour microenvironment to functionally interact with each other, with non-haematopoietic stromal cells and, ultimately, with cancer cells. These interactions regulate local immune cell survival, proliferative expansion, differentiation and their execution of pro-tumour or antitumour effector functions, which collectively determine the outcome of spontaneous or therapeutically induced antitumour immune responses. None of these interactions occur randomly but are orchestrated and critically depend on migratory guidance cues provided by chemokines, a large family of chemotactic cytokines, and their receptors. Understanding the functional organization of the tumour immune microenvironment inevitably requires knowledge of the multifaceted roles of chemokines in the recruitment and positioning of its cellular constituents. Gaining such knowledge will not only generate new insights into the mechanisms underlying antitumour immunity or immune tolerance but also inform the development of biomarkers (or ‘biopatterns’) based on spatial tumour tissue analyses, as well as novel strategies to therapeutically engineer immune responses in patients with cancer. Here we will discuss recent observations on the role of chemokines in the tumour microenvironment in the context of our knowledge of their physiological functions in development, homeostasis and antimicrobial responses.

摘要翻译： 

为了让我们的免疫系统能够遏制或消除恶性实体瘤，髓系和淋巴系造血细胞不仅必须从血液中外渗进入肿瘤组织，还需要进一步迁移到肿瘤微环境的各个特化区域，与其他免疫细胞、非造血基质细胞，并最终与癌细胞发生功能性相互作用。这些相互作用调控着局部免疫细胞的存活、增殖扩张、分化及其执行促肿瘤或抗肿瘤效应功能的过程，共同决定了自发或治疗诱导的抗肿瘤免疫反应的结果。这些相互作用并非随机发生，而是在趋化因子（一个庞大的趋化性细胞因子家族）及其受体提供的迁移引导信号的精密协调下进行的。理解肿瘤免疫微环境的功能组织，必然需要掌握趋化因子在细胞成分招募与定位中的多层面作用。获取这方面的知识不仅能深入揭示抗肿瘤免疫或免疫耐受的内在机制，还将为基于肿瘤组织空间分析的生物标志物（或“生物模式”）开发提供依据，并为癌症患者免疫反应的临床治疗工程化提供新策略。此处我们将结合趋化因子在发育、稳态和抗菌反应中的生理功能知识，探讨其在肿瘤微环境中作用的最新研究进展。

原文链接：

How chemokines organize the tumour microenvironment