文章：

Eph受体和ephrin在癌症进展中的作用

Eph receptors and ephrins in cancer progression

原文发布日期：2023-11-23

DOI: 10.1038/s41568-023-00634-x

类型: Review Article

开放获取: 否

英文摘要：

Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together make up the ‘Eph system’) in cancer development and progression has been accumulating since the discovery of the first Eph receptor approximately 35 years ago. Advances in the past decade and a half have considerably increased the understanding of Eph receptor–ephrin signalling mechanisms in cancer and have uncovered intriguing new roles in cancer progression and drug resistance. This Review focuses mainly on these more recent developments. I provide an update on the different mechanisms of Eph receptor–ephrin-mediated cell–cell communication and cell autonomous signalling, as well as on the interplay of the Eph system with other signalling systems. I further discuss recent advances in elucidating how the Eph system controls tumour expansion, invasiveness and metastasis, supports cancer stem cells, and drives therapy resistance. In addition to functioning within cancer cells, the Eph system also mediates the reciprocal communication between cancer cells and cells of the tumour microenvironment. The involvement of the Eph system in tumour angiogenesis is well established, but recent findings also demonstrate roles in immune cells, cancer-associated fibroblasts and the extracellular matrix. Lastly, I discuss strategies under evaluation for therapeutic targeting of Eph receptors–ephrins in cancer and conclude with an outlook on promising future research directions.

摘要翻译： 

自大约35年前首次发现Eph受体以来，越来越多的证据表明Eph受体酪氨酸激酶及其配体ephrin（共同构成“Eph系统”）参与癌症的发生发展。过去十五年的研究进展极大增进了我们对Eph受体-ephrin在癌症中信号传导机制的理解，并揭示了其在癌症进展和耐药性方面令人关注的新功能。本综述主要聚焦于这些最新研究进展，重点阐述Eph受体-ephrin介导的细胞间通讯与细胞自主信号传导机制，以及Eph系统与其他信号系统的相互作用。同时探讨Eph系统如何调控肿瘤扩张、侵袭与转移、维持癌症干细胞特性及驱动治疗耐药性的最新发现。除在癌细胞内部发挥作用外，Eph系统还介导癌细胞与肿瘤微环境细胞的双向通讯。该系统在肿瘤血管生成中的作用已明确，而最新研究还揭示了其在免疫细胞、癌症相关成纤维细胞和细胞外基质中的功能。最后，本文讨论了目前正在评估的Eph受体-ephrin靶向治疗策略，并对未来具有前景的研究方向进行展望。

原文链接：

Eph receptors and ephrins in cancer progression