文章：

干细胞样耗竭和记忆CD8+ T细胞在癌症中的作用

Stem-like exhausted and memory CD8+ T cells in cancer

原文发布日期：2023-10-11

DOI: 10.1038/s41568-023-00615-0

类型: Review Article

开放获取: 否

英文摘要：

T cells can acquire a broad spectrum of differentiation states following activation. At the extreme ends of this continuum are short-lived cells equipped with effector machinery and more quiescent, long-lived cells with heightened proliferative potential and stem cell-like developmental plasticity. The latter encompass stem-like exhausted T cells and memory T cells, both of which have recently emerged as key determinants of cancer immunity and response to immunotherapy. Here, we discuss key similarities and differences in the regulation and function of stem-like exhausted CD8+ T cells and memory CD8+ T cells, and consider their context-specific contributions to protective immunity in diverse outcomes of cancer, including tumour escape, long-term control and eradication. Finally, we emphasize how recent advances in the understanding of the molecular regulation of stem-like exhausted T cells and memory T cells are being explored for clinical benefit in cancer immunotherapies such as checkpoint inhibition, adoptive cell therapy and vaccination.

摘要翻译： 

T细胞在活化后可获得广泛的分化状态。该连续谱的两个极端末端分别是具备效应机制的短寿命细胞，以及具有更强增殖潜力和干细胞样发育可塑性的静息态长寿命细胞。后者包括干细胞样耗竭T细胞和记忆T细胞——这两类细胞近年来已成为癌症免疫及免疫疗法应答的关键决定因素。本文重点探讨干细胞样耗竭CD8+T细胞与记忆CD8+T细胞在调控机制和功能上的核心异同，并思考它们在不同癌症结局（包括肿瘤逃逸、长期控制和彻底清除）中对保护性免疫的具体贡献。最后，我们着重阐述了如何将干细胞样耗竭T细胞与记忆T细胞分子调控机制的最新认知应用于癌症免疫治疗（如检查点抑制、过继细胞疗法和疫苗接种）以获取临床效益。

原文链接：

Stem-like exhausted and memory CD8+ T cells in cancer