文章：

研究肿瘤生态系统的微工程和纳米工程方法

Micro-engineering and nano-engineering approaches to investigate tumour ecosystems

原文发布日期：2023-06-23

DOI: 10.1038/s41568-023-00593-3

类型: Review Article

开放获取: 否

英文摘要：

The interactions among tumour cells, the tumour microenvironment (TME) and non-tumour tissues are of interest to many cancer researchers. Micro-engineering approaches and nanotechnologies are under extensive exploration for modelling these interactions and measuring them in situ and in vivo to investigate therapeutic vulnerabilities in cancer and extend a systemic view of tumour ecosystems. Here we highlight the greatest opportunities for improving the understanding of tumour ecosystems using microfluidic devices, bioprinting or organ-on-a-chip approaches. We also discuss the potential of nanosensors that can transmit information from within the TME or elsewhere in the body to address scientific and clinical questions about changes in chemical gradients, enzymatic activities, metabolic and immune profiles of the TME and circulating analytes. This Review aims to connect the cancer biology and engineering communities, presenting biomedical technologies that may expand the methodologies of the former, while inspiring the latter to develop approaches for interrogating cancer ecosystems.

摘要翻译： 

肿瘤细胞、肿瘤微环境及非肿瘤组织间的相互作用是许多癌症研究者关注的焦点。微工程学方法和纳米技术正被广泛探索，用于模拟这些相互作用并在原位及体内进行测量，以研究癌症的治疗脆弱性并拓展对肿瘤生态系统的系统性认知。本文重点探讨了利用微流控设备、生物打印或芯片器官方法在深化肿瘤生态系统理解方面的重大机遇。我们同时讨论了纳米传感器的潜力，这些传感器能够从肿瘤微环境或体内其他部位传输信息，以解决关于化学梯度变化、酶活性、肿瘤微环境的代谢与免疫特征以及循环分析物的科学和临床问题。本综述旨在连接癌症生物学与工程学界，展示可拓展前者研究方法、同时激励后者开发探究癌症生态系统新途径的生物医学技术。

原文链接：

Micro-engineering and nano-engineering approaches to investigate tumour ecosystems