文章：

基于mRNA的癌症治疗

mRNA-based cancer therapeutics

原文发布日期：2023-06-13

DOI: 10.1038/s41568-023-00586-2

类型: Review Article

开放获取: 否

英文摘要：

Due to the fact that mRNA technology allows the production of diverse vaccines and treatments in a shorter time frame and with reduced expense compared to conventional approaches, there has been a surge in the use of mRNA-based therapeutics in recent years. With the aim of encoding tumour antigens for cancer vaccines, cytokines for immunotherapy, tumour suppressors to inhibit tumour development, chimeric antigen receptors for engineered T cell therapy or genome-editing proteins for gene therapy, many of these therapeutics have shown promising efficacy in preclinical studies, and some have even entered clinical trials. Given the evidence supporting the effectiveness and safety of clinically approved mRNA vaccines, coupled with growing interest in mRNA-based therapeutics, mRNA technology is poised to become one of the major pillars in cancer drug development. In this Review, we present in vitro transcribed mRNA-based therapeutics for cancer treatment, including the characteristics of the various types of synthetic mRNA, the packaging systems for efficient mRNA delivery, preclinical and clinical studies, current challenges and future prospects in the field. We anticipate the translation of promising mRNA-based treatments into clinical applications, to ultimately benefit patients.

摘要翻译： 

鉴于mRNA技术相比传统方法能在更短时间内以更低成本生产多种疫苗和治疗方法，近年来基于mRNA的疗法使用量激增。这些疗法通过编码肿瘤抗原用于癌症疫苗、细胞因子用于免疫治疗、抑癌基因抑制肿瘤发展、嵌合抗原受体用于工程化T细胞治疗，或基因组编辑蛋白用于基因治疗，其中许多已在临床前研究中展现显著疗效，部分甚至进入临床试验阶段。现有证据支持临床获批mRNA疫苗的有效性和安全性，加之对mRNA疗法日益增长的兴趣，该技术有望成为癌症药物研发的重要支柱之一。本综述重点介绍基于体外转录mRNA的癌症治疗方法，涵盖各类合成mRNA的特性、高效mRNA递送系统、临床前及临床研究、当前挑战与未来前景。我们期待将有潜力的mRNA疗法转化为临床应用，最终造福患者。

原文链接：

mRNA-based cancer therapeutics