文章：

YAP和TAZ在癌症中的最新发现和临床应用

Insights into recent findings and clinical application of YAP and TAZ in cancer

原文发布日期：2023-06-12

DOI: 10.1038/s41568-023-00579-1

类型: Review Article

开放获取: 否

英文摘要：

Decades of research have mapped out the basic mechanics of the Hippo pathway. The paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), as the central transcription control module of the Hippo pathway, have long been implicated in the progression of various human cancers. The current literature regarding oncogenic YAP and TAZ activities consists mostly of context-specific mechanisms and treatments of human cancers. Furthermore, a growing number of studies demonstrate tumour-suppressor functions of YAP and TAZ. In this Review we aim to synthesize an integrated perspective of the many disparate findings regarding YAP and TAZ in cancer. We then conclude with the various strategies for targeting and treating YAP- and TAZ-dependent cancers.

摘要翻译： 

数十年的研究已经揭示了Hippo信号通路的基本机制。作为该通路的核心转录控制模块，YAP蛋白及其同源物TAZ长期以来被认为与多种人类癌症的进展密切相关。当前关于致癌性YAP和TAZ活性的文献主要集中于特定肿瘤环境的机制及治疗方法。此外，越来越多研究证实YAP和TAZ具有肿瘤抑制功能。本篇综述旨在整合关于YAP和TAZ在癌症中众多不同发现的全景视角，最后总结针对YAP和TAZ依赖性癌症的各种靶向治疗策略。

原文链接：

Insights into recent findings and clinical application of YAP and TAZ in cancer