文章：

驱动癌细胞免疫调节功能的机制

Mechanisms driving the immunoregulatory function of cancer cells

原文发布日期：2023-01-30

DOI: 10.1038/s41568-022-00544-4

类型: Review Article

开放获取: 否

英文摘要：

Tumours display an astonishing variation in the spatial distribution, composition and activation state of immune cells, which impacts their progression and response to immunotherapy. Shedding light on the mechanisms that govern the diversity and function of immune cells in the tumour microenvironment will pave the way for the development of more tailored immunomodulatory strategies for the benefit of patients with cancer. Cancer cells, by virtue of their paracrine and juxtacrine communication mechanisms, are key contributors to intertumour heterogeneity in immune contextures. In this Review, we discuss how cancer cell-intrinsic features, including (epi)genetic aberrations, signalling pathway deregulation and altered metabolism, play a key role in orchestrating the composition and functional state of the immune landscape, and influence the therapeutic benefit of immunomodulatory strategies. Moreover, we highlight how targeting cancer cell-intrinsic parameters or their downstream immunoregulatory pathways is a viable strategy to manipulate the tumour immune milieu in favour of antitumour immunity.

摘要翻译： 

肿瘤在免疫细胞的空间分布、组成及活化状态上表现出惊人的多样性，这种多样性影响着肿瘤的进展及对免疫治疗的反应。揭示肿瘤微环境中免疫细胞多样性与功能调控机制，将为开发更精准的免疫调节策略、造福癌症患者铺平道路。癌细胞通过其旁分泌和近分泌通讯机制，成为肿瘤间免疫环境异质性的关键塑造者。本综述探讨了癌细胞内在特征——包括（表观）遗传异常、信号通路失调和代谢改变——如何在协调免疫景观的组成与功能状态中发挥关键作用，并影响免疫调节策略的治疗效益。此外，我们强调靶向癌细胞内在参数或其下游免疫调节通路，是通过重塑肿瘤免疫微环境促进抗肿瘤免疫的有效策略。

原文链接：

Mechanisms driving the immunoregulatory function of cancer cells