文章：

循环肿瘤细胞的生物学、脆弱性和临床应用

Biology, vulnerabilities and clinical applications of circulating tumour cells

原文发布日期：2022-12-09

DOI: 10.1038/s41568-022-00536-4

类型: Review Article

开放获取: 否

英文摘要：

In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading to new fields of research and fostering the promise for paradigm-changing, liquid biopsy-based clinical applications. Analysis of CTCs has revealed distinct biological phenotypes, including the presence of CTC clusters and the interaction between CTCs and immune or stromal cells, impacting metastasis formation and providing new insights into cancer vulnerabilities. Here we review the progress made in understanding biological features of CTCs and provide insight into exploiting these developments to design future clinical tools for improving the diagnosis and treatment of cancer.

摘要翻译： 

近年来，技术的卓越进步使得从患者血液样本中鉴定和研究稀有循环肿瘤细胞成为可能，这开辟了新的研究领域，并为基于液体活检的临床应用带来了改变范式的希望。对循环肿瘤细胞的分析揭示了独特的生物学表型，包括循环肿瘤细胞簇的存在以及循环肿瘤细胞与免疫细胞或基质细胞之间的相互作用，这些发现不仅影响转移灶的形成，也为探究癌症脆弱性提供了新视角。本文回顾了在理解循环肿瘤细胞生物学特征方面取得的进展，并探讨如何利用这些进展设计未来的临床工具，以改善癌症的诊断和治疗。

原文链接：

Biology, vulnerabilities and clinical applications of circulating tumour cells