文章：

马兜铃酸相关癌症：需要全球行动的公共卫生风险

Aristolochic acid-associated cancers: a public health risk in need of global action

原文发布日期：2022-07-19

DOI: 10.1038/s41568-022-00494-x

类型: Review Article

开放获取: 否

英文摘要：

Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe nephropathy, and urological and hepatobiliary cancers (among others) that are often recurrent and characterized by the prominent mutational fingerprint of AA. However, herbal medicinal products that contain AA continue to be manufactured and marketed worldwide with inadequate regulation, and possible environmental exposure routes receive little attention. As the trade of food and dietary supplements becomes increasingly globalized, we propose that further inaction on curtailing AA exposure will have far-reaching negative effects on the disease trends of AA-associated cancers. Our Review aims to systematically present the historical and current evidence for the mutagenicity and carcinogenicity of AA, and the effect of removing sources of AA exposure on cancer incidence trends. We discuss the persisting challenges of assessing the scale of AA-related carcinogenicity, and the obstacles that must be overcome in curbing AA exposure and preventing associated cancers. Overall, this Review aims to strengthen the case for the implementation of prevention measures against AA’s multifaceted, detrimental and potentially fully preventable effects on human cancer development.

摘要翻译： 

马兜铃酸是一类天然存在的化合物，广泛存在于马兜铃科多种植物中。接触马兜铃酸是导致严重肾病、泌尿系统及肝胆系统癌症（等疾病）的重要危险因素，这些疾病常反复发作，并具有典型的马兜铃酸突变特征。然而，含马兜铃酸的草药产品仍在全球范围内持续制造和销售，且监管不足，可能的环境暴露途径也鲜少受到关注。随着食品和膳食补充剂贸易日益全球化，我们认为若不再采取行动限制马兜铃酸暴露，将对马兜铃酸相关癌症的疾病趋势产生深远的负面影响。本综述旨在系统阐述马兜铃酸致突变性和致癌性的历史与当代证据，以及消除马兜铃酸暴露源对癌症发病率趋势的影响。我们讨论了评估马兜铃酸相关致癌性规模所面临的持续挑战，以及在遏制马兜铃酸暴露和预防相关癌症过程中必须克服的障碍。总体而言，本综述旨在为实施预防措施提供更有力的依据，以应对马兜铃酸对人类癌症发展产生的多层面、有害且可能完全可预防的影响。

原文链接：

Aristolochic acid-associated cancers: a public health risk in need of global action