文章：

脑癌干细胞：通过适应性可塑性和层次异质性的恢复力

Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity

原文发布日期：2022-06-16

DOI: 10.1038/s41568-022-00486-x

类型: Review Article

开放获取: 否

英文摘要：

Malignant brain tumours are complex ecosystems containing neoplastic and stromal components that generate adaptive and evolutionarily driven aberrant tissues in the central nervous system. Brain cancers are cultivated by a dynamic population of stem-like cells that enforce intratumoural heterogeneity and respond to intrinsic microenvironment or therapeutically guided insults through proliferation, plasticity and restructuring of neoplastic and stromal components. Far from a rigid hierarchy, heterogeneous neoplastic populations transition between cellular states with differential self-renewal capacities, endowing them with powerful resilience. Here we review the biological machinery used by brain tumour stem cells to commandeer tissues in the intracranial space, evade immune responses and resist chemoradiotherapy. Through recent advances in single-cell sequencing, improved models to investigate the role of the tumour microenvironment and a deeper understanding of the fundamental role of the immune system in cancer biology, we are now better equipped to explore mechanisms by which these processes can be exploited for therapeutic benefit.

摘要翻译： 

恶性脑肿瘤是复杂的生态系统，包含肿瘤细胞和基质成分，这些成分在中枢神经系统内形成适应性强且进化驱动的异常组织。脑癌由动态的类干细胞群体培育而成，这些细胞强化了肿瘤内异质性，并能通过增殖、可塑性及肿瘤与基质组分的重构，响应内在微环境或治疗性干预。异质性肿瘤群体远非僵化的层级结构，而是在具有差异自我更新能力的细胞状态间转换，赋予其强大的适应力。本文综述脑肿瘤干细胞用于占据颅内组织、逃避免疫反应及抵抗放化疗的生物学机制。借助单细胞测序技术的最新进展、研究肿瘤微环境作用的改进模型，以及对免疫系统在癌症生物学中基础作用的深入理解，我们现在能更好地探索如何利用这些机制实现治疗目标。

原文链接：

Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity