文章：

靶向铁下垂作为癌症易感性

Targeting ferroptosis as a vulnerability in cancer

原文发布日期：2022-03-25

DOI: 10.1038/s41568-022-00459-0

类型: Review Article

开放获取: 否

英文摘要：

Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered enormous interest in cancer research communities, partly because it is a unique cell death modality that is mechanistically and morphologically different from other forms of cell death, such as apoptosis, and therefore holds great potential for cancer therapy. In this Review, we summarize the current understanding of ferroptosis-inducing and ferroptosis defence mechanisms, dissect the roles and mechanisms of ferroptosis in tumour suppression and tumour immunity, conceptualize the diverse vulnerabilities of cancer cells to ferroptosis, and explore therapeutic strategies for targeting ferroptosis in cancer.

摘要翻译： 

铁死亡是一种铁依赖性的调控性细胞死亡形式，由细胞膜上脂质过氧化物的毒性积聚引发。近年来，铁死亡在癌症研究领域引起了极大关注，部分原因在于其独特的细胞死亡模式——在作用机制和形态学上均不同于其他细胞死亡形式（如凋亡），因此展现出巨大的癌症治疗潜力。本综述将总结当前对铁死亡诱导与防御机制的认识，剖析铁死亡在肿瘤抑制和肿瘤免疫中的作用与机制，系统归纳癌细胞对铁死亡的多样性脆弱点，并探索针对铁死亡的癌症治疗策略。

原文链接：

Targeting ferroptosis as a vulnerability in cancer