文章：

利用衰老来治疗癌症

Exploiting senescence for the treatment of cancer

原文发布日期：2022-03-03

DOI: 10.1038/s41568-022-00450-9

类型: Review Article

开放获取: 否

英文摘要：

Senescence is a cellular response to a variety of stress signals that is characterized by a stable withdrawal from the cell cycle and major changes in cell morphology and physiology. While most research on senescence has been performed on non-cancer cells, it is evident that cancer cells can also mount a senescence response. In this Review, we discuss how senescence can be induced in cancer cells. We describe the distinctive features of senescent cancer cells and how these changes in cellular physiology might be exploited for the selective eradication of these cells (senolysis). We discuss activation of the host immune system as a particularly attractive way to clear senescent cancer cells. Finally, we consider the challenges and opportunities provided by a ‘one-two punch’ sequential treatment of cancer with pro-senescence therapy followed by senolytic therapy.

摘要翻译： 

细胞衰老是细胞对多种应激信号产生的反应，其特点是稳定退出细胞周期并发生细胞形态与生理学的显著改变。虽然大多数关于衰老的研究是在非癌细胞中进行的，但癌细胞显然也能启动衰老应答。本综述将探讨诱导癌细胞衰老的机制，阐述衰老癌细胞的显著特征，以及如何利用这些细胞生理学变化实现选择性清除衰老细胞（衰老细胞清除）。我们讨论了激活宿主免疫系统作为清除衰老癌细胞的一种特别有吸引力的策略。最后，我们分析了采用“连续重击”疗法——即先进行促衰老治疗再进行衰老细胞清除治疗——所面临的挑战与机遇。

原文链接：

Exploiting senescence for the treatment of cancer